| NOx (nitrite/nitrate) in patients with pediatric nephrotic syndrome. | |
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MedLine Citation:
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PMID: 17287970 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To better understand the role of nitric oxide (NO) in pediatric nephrotic syndrome, we measured nitrite/nitrate (NOx) [NO2- and NO3-] in serum obtained from patients with several pediatric kidney diseases and investigated the locations of endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS). NOx in serum showed significantly higher levels than those in healthy controls (mean +/- SE: 297 +/- 55.7 vs. 158 +/- 13.1 pmol/10 microl). There was no significant difference between six patients with frequent relapse and five patients with nonfrequent relapse. The studies with immunostaining of iNOS and nitrotyrosine were negative for glomerulus in patients with nephrotic syndrome. Those findings suggest that NOx might indirectly influence disease progression in nephrotic syndrome. |
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Authors:
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Hisashi Kawashima; Yasuyo Kashiwagi; Chiako Watanabe; Satoshi Sato; Shigeo Nishimata; Kouji Takekuma; Akinori Hoshika; Yasuo Watanabe |
Publication Detail:
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Type: Journal Article Date: 2007-02-08 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 22 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-04-18 Completed Date: 2007-07-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 840-3 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan. hisashi@tokyo-med.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Biological Markers / metabolism Child Child, Preschool Female Humans Immunoenzyme Techniques Infant Kidney Glomerulus / enzymology, pathology Male Nephrotic Syndrome / blood*, pathology Nitrates / blood* Nitric Oxide Synthase Type II / metabolism* Nitric Oxide Synthase Type III / metabolism* Nitrites / blood* Recurrence |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Nitrates; 0/Nitrites; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 1.14.13.39/Nitric Oxide Synthase Type III |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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