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Is NOX2 up-regulation implicated in myocardial injury in patients with pneumonia?
MedLine Citation:
PMID:  24328853     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In the present study, we tested the hypothesis that oxidative stress could be implicated in myocardial damage during the acute phase of pneumonia. NOX2 activation, the catalytic sub-unit of NADPH oxidase, and high-sensitivity cardiac troponin T elevation (hs-cTnT) have been analysed in two-hundred-forty-eight consecutive patients hospitalized for community-acquired pneumonia. Serum NOX2-derived peptide (sNOX2-dp), a marker of NOX2 activation, and 8-iso-PGF2α, a marker of oxidative stress, were measured upon admission; serum hs-cTnT and ECG were measured every 12 and 24 hours, respectively. One hundred thirty-five patients (54%) showed elevated serum levels of hs-cTnT (> 0.014 µg/L). A logistic regression analysis showed sNOX2-dp (p<0.001), Pneumonia Severity Index score (p<0.001), renal failure (p=0.024) and ejection fraction (p<0.001) as independent predictors of elevated serum levels of hs-cTnT. Serum sNOX2-dp was linearly correlated with hs-cTnT (Rs=0.538; p<0.001) and 8-iso-PGF2α (Rs=0.354; p<0.001). The study provides the first evidence of a significant association between serum cardiac Troponin T elevation and NOX2 up-regulation in patients with pneumonia. This finding raises the hypothesis that NOX2-derived oxidative stress may be implicated in myocardial injury and that its inhibition could be a novel therapeutic strategy to limit it.
Authors:
Roberto Cangemi; Camilla Calvieri; Tommaso Bucci; Roberto Carnevale; Marco Casciaro; Elisabetta Rossi; Cinzia Myriam Calabrese; Gloria Taliani; Stefania Grieco; Marco Falcone; Paolo Palange; Giuliano Bertazzoni; Andrea Celestini; Pasquale Pignatelli; Francesco Violi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-13
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  -     ISSN:  1557-7716     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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