| NOX2 Complex-Derived ROS as Immune Regulators. | |
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MedLine Citation:
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PMID: 20919938 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Abstract Reactive oxygen species (ROS) are a heterogeneous group of highly reactive molecules that oxidize targets in a biologic system. During steady-state conditions, ROS are constantly produced in the electron-transport chain during cellular respiration and by various constitutively active oxidases. ROS production can also be induced by activation of the phagocyte NADPH oxidase 2 (NOX2) complex in a process generally referred to as an oxidative burst. The induced ROS have long been considered proinflammatory, causing cell and tissue destruction. Recent findings have challenged this inflammatory role of ROS, and today, ROS are also known to regulate immune responses and cell proliferation and to determine T-cell autoreactivity. NOX2-derived ROS have been shown to suppress antigen-dependent T-cell reactivity and remarkably to reduce the severity of experimental arthritis in both rats and mice. In this review, we discuss the role of ROS and the NOX2 complex as suppressors of autoimmunity, inflammation, and arthritis. Antioxid. Redox Signal. 15, 2197-2208. |
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Authors:
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Outi Sareila; Tiina Kelkka; Angela Pizzolla; Malin Hultqvist; Rikard Holmdahl |
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Publication Detail:
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Type: Journal Article Date: 2011-04-11 |
Journal Detail:
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Title: Antioxidants & redox signaling Volume: 15 ISSN: 1557-7716 ISO Abbreviation: Antioxid. Redox Signal. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: United States |
Other Details:
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Languages: eng Pagination: 2197-208 Citation Subset: IM |
Affiliation:
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1 MediCity Research Laboratory, University of Turku , Turku, Finland . |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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