Document Detail


NOS3 genotype-dependent correlation between blood pressure and physical activity.
MedLine Citation:
PMID:  12574107     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Endothelium-dependent vasorelaxation plays an important role in reduction of blood pressure and is mediated through release of nitric oxide (NO), which is generated by constitutively expressed endothelial nitric oxide synthase (NOS3). Exercise also augments NO release and has been recommended for primary prevention and improvement of hypertension, but individual responses are highly variable. We therefore postulated that genetic polymorphisms of NOS3 might interact with physical activity level to differentially influence blood pressure level. We genotyped 832 healthy Japanese (mean age of 54.4+/-8.6 years, 372 men and 460 women) for a polymorphism of NOS3 in intron 4 (ecNOS4a/b), using the polymerase chain reaction method, and scored their habitual physical activity level by using the rate of energy expenditure per resting metabolic rate through an interview according to a semiquantitative assessment method. Only in the subjects who had the rarer a allele (aa+ba type), systolic blood pressure was found to be inversely correlated with physical activity level (P for linear trend=0.0496, for interaction=0.0071). Eventually, this polymorphism was significantly associated with the prevalence of systolic hypertension only in the subjects who were in the lowest tertile of physical activity level (OR=2.4, 95% CI, 1.1 to 5.6, P for interaction=0.0474). In the present study, we found a significant interaction between the genotype and physical activity level on systolic blood pressure. These results might allow a better understanding of the mechanism to improve hypertension by exercise and to thereby reduce the risk of cardiovascular disease.
Authors:
Tomomi Kimura; Tetsuji Yokoyama; Yasuhiro Matsumura; Nobuo Yoshiike; Chigusa Date; Masaaki Muramatsu; Heizo Tanaka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension     Volume:  41     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-07     Completed Date:  2003-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  355-60     Citation Subset:  IM    
Affiliation:
Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan. kimura.epi@mri.tmd.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Alleles
Analysis of Variance
Blood Pressure / physiology*
Cross-Sectional Studies
Exercise / physiology
Female
Gene Frequency
Genotype
Humans
Hypertension / genetics,  physiopathology
Introns / genetics
Male
Middle Aged
Nitric Oxide Synthase / genetics*
Nitric Oxide Synthase Type III
Odds Ratio
Physical Fitness / physiology*
Polymorphism, Genetic
Chemical
Reg. No./Substance:
EC 1.14.13.39/NOS3 protein, human; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.14.13.39/Nitric Oxide Synthase Type III

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