Document Detail

NOS inhibition restores renal responses to atrial distension during pregnancy.
MedLine Citation:
PMID:  11959677     Owner:  NLM     Status:  MEDLINE    
Nitric oxide (NO) biosynthesis increases during pregnancy and has been shown to suppress baroreceptor activity. The renal response to a simulated increase in circulating blood volume (atrial distension) is also attenuated at this time. We hypothesized that blocking NO biosynthesis during pregnancy would restore the renal response. Female rats were implanted with indwelling intracardiac balloons and central venous cannulas. After recovery, they were mated, and on day 14 of pregnancy, osmotic minipumps containing the NO synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) or its inactive enantiomer N(G)-nitro-D-arginine methyl ester (D-NAME) (120 mg/2 ml at 10 microg/min) were implanted. In response to atrial distension (1 h), urine output increased in the D- and L-NAME-treated virgin rats. During pregnancy (day 20), this response was attenuated in the D-NAME-treated, but not the L-NAME-treated, animals, i.e., after a simulated increase in circulating blood volume, inhibition of NO biosynthesis restored the renal response of pregnant rats to that seen in virgin animals. We conclude that, during normal pregnancy, increased NO biosynthesis blunts the reflex renal response to atrial distension.
Siu Lin Tam; Susan Kaufman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  282     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-04-17     Completed Date:  2002-05-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R1364-7     Citation Subset:  IM    
Department of Physiology, University of Alberta, Edmonton, Alberta, Canada T6G 2S2.
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MeSH Terms
Atrial Function*
Blood Volume / physiology*
Diuresis / drug effects,  physiology
Enzyme Inhibitors / pharmacology
Kidney / physiology*
NG-Nitroarginine Methyl Ester / pharmacology
Nitric Oxide Synthase / antagonists & inhibitors*
Pregnancy, Animal / physiology*
Reg. No./Substance:
0/Enzyme Inhibitors; 50903-99-6/NG-Nitroarginine Methyl Ester; EC Oxide Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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