| NOD1-Mediated Mucosal Host Defense against Helicobacter pylori. | |
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MedLine Citation:
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PMID: 21152124 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Infection of the stomach with Helicobacter pylori is an important risk factor for gastritis, peptic ulcer, and gastric carcinoma. Although it has been well established that persistent colonization by H. pylori is associated with adaptive Th1 responses, the innate immune responses leading to these Th1 responses are poorly defined. Recent studies have shown that the activation of nucleotide-binding oligomerization domain 1 (NOD1) in gastric epithelial cells plays an important role in innate immune responses against H. pylori. The detection of H. pylori-derived ligands by cytosolic NOD1 induces several host defense factors, including antimicrobial peptides, cytokines, and chemokines. In this paper, we review the molecular mechanisms by which NOD1 contributes to mucosal host defense against H. pylori infection of the stomach. |
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Authors:
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Tomohiro Watanabe; Naoki Asano; Atsushi Kitani; Ivan J Fuss; Tsutomu Chiba; Warren Strober |
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Publication Detail:
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Type: Journal Article Date: 2010-07-15 |
Journal Detail:
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Title: International journal of inflammation Volume: 2010 ISSN: 2042-0099 ISO Abbreviation: Int J Inflam Publication Date: 2010 |
Date Detail:
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Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101538188 Medline TA: Int J Inflam Country: England |
Other Details:
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Languages: eng Pagination: 476482 Citation Subset: - |
Affiliation:
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Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10-CRC Room 5W3940, 10 Center Drive, Bethesda, MD 20892, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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