Document Detail

NO is not involved in the simvastatin induced cell division and differentiation in PC12 cells.
MedLine Citation:
PMID:  9535116     Owner:  NLM     Status:  MEDLINE    
Simvastatin, a potent 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor has been reported to inhibit cell division and induce neurite-like outgrowth in PC12 cells [Sato-Suzuki, I. and Murota, S., Neurosci. Lett., 220 (1996) 21-24]. In the present paper, we examined whether the induced nitric oxide (NO) in the simvastatin-treated PC12 cells is involved in the growth arrest and differentiation as reported in nerve growth factor (NGF) treated PC12 cells. Treatment of PC12 cells with simvastatin caused peripherin formation and enhanced NO production just like NGF-treated PC12 cells. Different from NGF, however, NO synthase inhibitors could not affect the growth arrest and differentiation in simvastatin-treated PC12 cells. In conclusion, NO had nothing to do with cell division and differentiation in simvastatin-treated PC12 cells.
M Sano; I Sato-Suzuki; H Fujita; I Morita; M Nagao; S Murota
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  243     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-05-14     Completed Date:  1998-05-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  73-6     Citation Subset:  IM    
Department of Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, Japan.
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MeSH Terms
Cell Differentiation / drug effects
Cell Division / drug effects
Dose-Response Relationship, Drug
Enzyme Inhibitors / pharmacology
Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
Intermediate Filament Proteins / analysis
Membrane Glycoproteins*
NG-Nitroarginine Methyl Ester / pharmacology
Nerve Tissue Proteins / analysis
Neurites / chemistry,  drug effects,  enzymology
Neurons / cytology,  drug effects*,  ultrastructure
Nitric Oxide / physiology*
PC12 Cells
Simvastatin / pharmacology*
omega-N-Methylarginine / pharmacology
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Intermediate Filament Proteins; 0/Membrane Glycoproteins; 0/Nerve Tissue Proteins; 0/peripherin; 10102-43-9/Nitric Oxide; 17035-90-4/omega-N-Methylarginine; 50903-99-6/NG-Nitroarginine Methyl Ester; 79902-63-9/Simvastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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