| NO-mediated alterations in skeletal muscle nutritive blood flow and lactate metabolism in fibromyalgia. | |
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MedLine Citation:
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PMID: 16376018 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of these investigations was to determine if differences exist in skeletal muscle nutritive blood flow and lactate metabolism in women with fibromyalgia (FM) compared to healthy women (HC); furthermore, to determine if differences in nitric oxide-mediated systems account for any detected alterations in blood flow and lactate metabolism and contribute to exertional fatigue in FM. FM (n = 8) and HC (n = 8) underwent a cycle ergometry test of aerobic capacity, a muscle biopsy for determination of nitric oxide synthase (eNOS, nNOS, iNOS) content, and microdialysis for investigation of muscle nutritive blood flow and lactate metabolism. During prolonged (3h) resting conditions, the ethanol outflow/inflow ratio (inversely related to blood flow) increased in FM over time compared to HC (P < 0.05). FM also exhibited a reduced nutritive blood flow response to aerobic exercise (P < 0.05). There was an increase in dialysate lactate in response to acetylcholine in FM, and to sodium nitroprusside in both groups, with a greater rise in dialysate lactate in FM (P < 0.05). The iNOS protein content was higher in FM and was negatively correlated with total exercise time (r(2) = 0.462, P < 0.05). In conclusion: (1) There is reduced nutritive flow response to aerobic exercise and reduced maximal exercise time in FM that might relate to higher iNOS protein content and contribute to exertional fatigue in FM; (2) The increased dialysate lactate in FM in response to stimulation of NOS or a nitric oxide donor suggest that FM may be more sensitive than HC to the suppressive effect of nitric oxide on oxidative phosphorylation. |
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Authors:
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K L McIver; C Evans; R M Kraus; L Ispas; V M Sciotti; R C Hickner |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2005-12-22 |
Journal Detail:
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Title: Pain Volume: 120 ISSN: 0304-3959 ISO Abbreviation: Pain Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-01-17 Completed Date: 2006-03-30 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7508686 Medline TA: Pain Country: Netherlands |
Other Details:
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Languages: eng Pagination: 161-9 Citation Subset: IM |
Affiliation:
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Human Performance Laboratory, Department of Exercise and Sport Science, East Carolina University, Greenville, NC 27858, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Anaerobic Threshold* Blood Flow Velocity* Female Fibromyalgia / pathology, physiopathology* Humans Lactic Acid / metabolism* Middle Aged Muscle, Skeletal / blood supply, pathology, physiopathology* Nitric Oxide / metabolism* Nitric Oxide Synthase / metabolism* Physical Exertion |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 50-21-5/Lactic Acid; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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