Document Detail

NO-cGMP signaling molecules in the rat epithelial rests of Malassez.
MedLine Citation:
PMID:  14871194     Owner:  NLM     Status:  MEDLINE    
The epithelial rests of Malassez (ERM) are derived from the disintegrating epithelial root sheath of Hertwig that guides root formation during tooth development. Low concentrations of nitric oxide (NO) produced by NO-synthase I (NOS I) and NOS III activate intracellular soluble guanylate cyclase (sGC) to produce intracellular cyclic guanosine 3':5'-monophosphate (cGMP), which triggers rapid cellular responses such as cell proliferation, cell differentiation, and apoptosis under physiological conditions. The presence of NOS I-III, sGC (alpha2- and beta1-subunits) and cGMP in the ERM was investigated by immunohistochemistry. Rat molars with periodontium were perfusion and postfixed, decalcified, frozen-sectioned, and sections were immunostained. NOS I, NOS III, sGC (alpha2- and beta1-subunits) and cGMP were localized with different densities in the ERM. The presence of NOS II in the ERM varied. The localization of NOS I, NOS III, sGC and cGMP in the ERM indicates an involvement of NO and/or NO-cGMP signal pathway molecules in homeostasis of a variety of physiological processes in the ERM. These could include regulation of cell proliferation, cell differentiation and apoptosis.
Yüksel Korkmaz; Wilhelm Bloch; Sönke Behrends; Hannsjörg Schröder; Klaus Addicks; Michael A Baumann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of oral sciences     Volume:  112     ISSN:  0909-8836     ISO Abbreviation:  Eur. J. Oral Sci.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-11     Completed Date:  2004-04-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9504563     Medline TA:  Eur J Oral Sci     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  55-60     Citation Subset:  D; IM    
Department of Operative and Preventive Dentistry and Endodontics, Heinrich-Heine-University, Düsseldorf, Germany.
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MeSH Terms
Cyclic GMP / analysis*,  physiology
Epithelial Cells / chemistry,  enzymology
Guanylate Cyclase / analysis*
Nitric Oxide / metabolism
Nitric Oxide Synthase / analysis*
Periodontal Ligament / chemistry,  cytology,  enzymology*
Rats, Wistar
Second Messenger Systems*
Reg. No./Substance:
10102-43-9/Nitric Oxide; 7665-99-8/Cyclic GMP; EC Oxide Synthase; EC Cyclase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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