Document Detail


NO-cGMP signaling molecules in the rat epithelial rests of Malassez.
MedLine Citation:
PMID:  14871194     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The epithelial rests of Malassez (ERM) are derived from the disintegrating epithelial root sheath of Hertwig that guides root formation during tooth development. Low concentrations of nitric oxide (NO) produced by NO-synthase I (NOS I) and NOS III activate intracellular soluble guanylate cyclase (sGC) to produce intracellular cyclic guanosine 3':5'-monophosphate (cGMP), which triggers rapid cellular responses such as cell proliferation, cell differentiation, and apoptosis under physiological conditions. The presence of NOS I-III, sGC (alpha2- and beta1-subunits) and cGMP in the ERM was investigated by immunohistochemistry. Rat molars with periodontium were perfusion and postfixed, decalcified, frozen-sectioned, and sections were immunostained. NOS I, NOS III, sGC (alpha2- and beta1-subunits) and cGMP were localized with different densities in the ERM. The presence of NOS II in the ERM varied. The localization of NOS I, NOS III, sGC and cGMP in the ERM indicates an involvement of NO and/or NO-cGMP signal pathway molecules in homeostasis of a variety of physiological processes in the ERM. These could include regulation of cell proliferation, cell differentiation and apoptosis.
Authors:
Yüksel Korkmaz; Wilhelm Bloch; Sönke Behrends; Hannsjörg Schröder; Klaus Addicks; Michael A Baumann
Related Documents :
21764444 - Hypoxia inhibits invasion of extravillous trophoblast cells through reduction of matrix...
8300194 - Regulation of c6 glioma cell steroidogenesis by adenosine 3',5'-cyclic monophosphate.
2432184 - Atrial natriuretic factors stimulate accumulation and efflux of cyclic gmp in c6-2b rat...
2545854 - Stimulatory and inhibitory effects of forskolin on adenylate cyclase in rat normal hepa...
1238124 - Cell cycle dependent exposure of a high molecular weight protein on the surface of mous...
11264004 - Osteoclast differentiation factor modulates cell cycle machinery and causes a delay in ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of oral sciences     Volume:  112     ISSN:  0909-8836     ISO Abbreviation:  Eur. J. Oral Sci.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-11     Completed Date:  2004-04-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9504563     Medline TA:  Eur J Oral Sci     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  55-60     Citation Subset:  D; IM    
Affiliation:
Department of Operative and Preventive Dentistry and Endodontics, Heinrich-Heine-University, Düsseldorf, Germany. y.kormaz@uni-koeln.de
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cyclic GMP / analysis*,  physiology
Densitometry
Epithelial Cells / chemistry,  enzymology
Guanylate Cyclase / analysis*
Immunohistochemistry
Male
Nitric Oxide / metabolism
Nitric Oxide Synthase / analysis*
Periodontal Ligament / chemistry,  cytology,  enzymology*
Rats
Rats, Wistar
Second Messenger Systems*
Chemical
Reg. No./Substance:
10102-43-9/Nitric Oxide; 7665-99-8/Cyclic GMP; EC 1.14.13.39/Nitric Oxide Synthase; EC 4.6.1.2/Guanylate Cyclase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  T-cell costimulatory capacity of oral and skin epithelial cells in vitro: presence of suppressive ac...
Next Document:  Susceptibility of deciduous and permanent enamel to dietary acid-induced erosion studied with atomic...