| NO Is a Macrophage Autonomous Modifier of the Cytokine Response to Streptococcal Single-Stranded RNA. | |
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MedLine Citation:
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PMID: 22184724 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Group B streptococci, a major cause of sepsis, induce inflammatory cytokines in strict dependence on bacterial ssRNA and the host molecules MyD88 and UNC-93B. In this study, we show that NO plays an important role in Group B streptococci-induced transcriptional activation of cytokine genes. Phagocytosis induced NO in a MyD88-dependent fashion. In turn, NO propagated the acidification of phagosomes and the processing of phagosomal bacterial nucleic acids and was required for potent transcriptional activation of cytokine genes by streptococci. This NO-dependent amplification loop has important mechanistic implications for the anti-streptococcal macrophage response and sepsis pathogenesis. |
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Authors:
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Sachin D Deshmukh; Sabrina Müller; Katrin Hese; Katharina S Rauch; Julia Wennekamp; Osamu Takeuchi; Shizuo Akira; Douglas T Golenbock; Philipp Henneke |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-19 |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: - ISSN: 1550-6606 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Center of Chronic Immunodeficiency, Medical Center, University of Freiburg, 79106 Freiburg, Germany; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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