Document Detail


NMR study of per(3,6-anhydro) alpha cyclodextrin as a potential agent for the biological decontamination of lead.
MedLine Citation:
PMID:  9440354     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability of per(3,6-anhydro) alpha cyclodextrin(3,6CD) to capture lead from a preformed glutathion (GSH)-lead complex was investigated by NMR spectroscopy. Such a removal strongly depends on the nature and pH of the buffer used in the competition experiments. It was found that an almost complete removal of lead can be achieved at pH 5.5, especially when lead nitrate is used. The capture also strongly depends on the nature of the lead species as well as of the counter ion present in the medium. These observations imply that decontamination of lead by this process should be optimal under acidic conditions, i.e. in the acidic tractus (stomach). Conversely, lead decontamination at neutral pH was of poor efficiency or required a large excess of (3,6CD). This was particularly the case when human plasma was used as solvent.
Authors:
J C Debouzy; F Fauvelle; L Girault
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Bollettino chimico farmaceutico     Volume:  136     ISSN:  0006-6648     ISO Abbreviation:  Boll Chim Farm     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1998-03-02     Completed Date:  1998-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372534     Medline TA:  Boll Chim Farm     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  605-9     Citation Subset:  IM    
Affiliation:
CRSSA, U. Biophysique, La Tronche, France.
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MeSH Terms
Descriptor/Qualifier:
Chelating Agents / chemistry,  pharmacology*
Cyclodextrins / chemistry,  pharmacology*
Humans
Lead / blood*,  chemistry
Magnetic Resonance Spectroscopy
alpha-Cyclodextrins*
Chemical
Reg. No./Substance:
0/Chelating Agents; 0/Cyclodextrins; 0/alpha-Cyclodextrins; 0/per(3,6-anhydro)-alpha-cyclodextrin; 7439-92-1/Lead

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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