| NMR imaging of the apparent diffusion coefficient (ADC) for the evaluation of metabolic suppression and recovery after prolonged cerebral ischemia. | |
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MedLine Citation:
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PMID: 8063868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adult normothermic cats were submitted to 1-h complete cerebrocirculatory arrest by intrathoracic occlusion of the internal mammary, the innominate, and the subclavian arteries in combination with pharmacologically induced hypotension. After ischemia, recirculation was initiated at different blood pressure levels to manipulate the postischemia resuscitation conditions. The resulting spectrum of postischemic recovery was studied by combining nuclear magnetic resonance imaging of the apparent diffusion coefficient (ADC) with pictorial assays of brain tissue pH, ATP, glucose, and lactate. Before ischemia, the mean ADC (average of seven coronal slices of five cats) was 713 +/- 40 x 10(-6) mm2/s. After 10-min ischemia, ADC declined to 68% of control and after 50 min slightly further to 63% of control. During recirculation after 1-h ischemia, recovery of ADC varied depending on the initial reperfusion pressure and other systemic variables. In two animals ADC only transiently increased followed by a secondary decline below the postischemic level. In three other animals ADC returned to near control within 1 h of recirculation. The comparison of ADC changes with previously reported changes in extracellular volume revealed a close relationship, supporting the notion that ADC is a function of the intra/extracellular water compartmentation. Recovery of ADC correlated closely with tissue pH and metabolic recovery, studied 3 h after the initiation of recirculation. Animals without recovery of ADC exhibited global depletion of ATP and glucose and severe lactacidosis, whereas animals with recovery of ADC showed replenishment of ATP and glucose to near control and a substantial reversal of lactacidosis.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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K A Hossmann; M Fischer; K Bockhorst; M Hoehn-Berlage |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 14 ISSN: 0271-678X ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 1994 Sep |
Date Detail:
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Created Date: 1994-09-20 Completed Date: 1994-09-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 723-31 Citation Subset: IM |
Affiliation:
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Max-Planck-Institute for Neurological Research, Department of Experimental Neurology, Cologne, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Fluid Compartments* Brain Ischemia / metabolism* Cats Female Hydrogen-Ion Concentration Image Processing, Computer-Assisted Magnetic Resonance Imaging / methods* Male Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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