| NMR-based Metabolomic Studies on Urine and Serum Biochemical Profiles after Chronic Cysteamine Supplementation in Rats. | |
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MedLine Citation:
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PMID: 21476594 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The purpose of this study was to investigate the effect of chronic cysteamine (CS) supplementation on rat metabolism. Rats received biweekly intragastric administration of either CS-HCl at 250 mg/kg body weight or saline (control) for four weeks. Twenty-four-hour urine and blood serum samples after the last CS treatment were analyzed by NMR-based metabolomics, specifically high-resolution 1H NMR metabolic profiling combined with multivariate statistics. Metabolic effects of CS include decreased serum acetate, and trimethylamine-N-oxide, and urine hippurate together with increased urine dimethylamine, indicating modulation of intestinal microbial metabolism of the rats. A decrease in urine succinate, citric acid, and serum acetoacetate, together with an increase in serum lactate, was also observed, which suggests that CS supplementation results in perturbation of energy metabolism in rats. |
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Authors:
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Guangmang Liu; Yi Wang; Zhisheng Wang; Jingyi Cai; Xingzuo Lv; Anguo Zhou |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-9 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: - ISSN: 1520-5118 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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