Document Detail


NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 1.
MedLine Citation:
PMID:  23325512     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Members of the fibroblast growth factor receptor tyrosine kinase family (FGFR1-4) play an important role in many signalling cascades. Although tightly regulated, aberrant activity of these enzymes may lead to, or become features of, disease pathologies including cancer. FGFR isoforms have been the subject of drug discovery programmes, with a number of kinase-domain inhibitors in pre-clinical and clinical development. Here, we present the first (83 % complete) backbone resonance assignments of apo-FGFR1 kinase.
Authors:
Navratna Vajpai; Anne-Kathrin Schott; Martin Vogtherr; Alexander L Breeze
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  Biomolecular NMR assignments     Volume:  -     ISSN:  1874-270X     ISO Abbreviation:  Biomol NMR Assign     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101472371     Medline TA:  Biomol NMR Assign     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Protein Structure and Biophysics, AstraZeneca R&D, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK.
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