Document Detail

NMDA receptors mediate expression of one form of functional plasticity induced by olfactory deprivation.
MedLine Citation:
PMID:  7552248     Owner:  NLM     Status:  MEDLINE    
Unilateral olfactory deprivation for the first 3 postnatal weeks results in an enhancement of granule cell mediated, feedback inhibition of mitral cells in the rat olfactory bulb. Granule cells are excited by mitral cells by both non-NMDA and NMDA receptors. The present report describes the effect of the NMDA antagonist MK-801 (0.75 mg/kg) on the expression of deprivation enhanced inhibition. The results demonstrate that (1) enhancement of lateral olfactory tract paired-pulse inhibition of evoked potentials in deprived bulbs was stimulus intensity dependent, with the greatest difference expressed at highest stimulus intensities; (2) MK-801 reduced inhibition in both undeprived and deprived bulbs in a stimulus intensity dependent manner, with the greatest reduction occurring at highest stimulus intensities; (3) MK-801 eliminated the stimulus intensity effect on inhibition in both groups; and (4) following MK-801, deprived bulbs showed the same or less inhibition than undeprived bulbs.
D A Wilson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  677     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-11-14     Completed Date:  1995-11-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  238-42     Citation Subset:  IM    
Department of Zoology, University of Oklahoma, Norman 73019, USA.
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MeSH Terms
Animals, Newborn
Dizocilpine Maleate / pharmacology
Evoked Potentials / drug effects
Neural Inhibition / physiology
Neuronal Plasticity / physiology*
Neurons / physiology
Olfactory Bulb / physiology*
Rats, Wistar
Receptors, N-Methyl-D-Aspartate / physiology*
Sensory Deprivation / physiology*
Grant Support
Reg. No./Substance:
0/Receptors, N-Methyl-D-Aspartate; 77086-22-7/Dizocilpine Maleate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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