Document Detail

NMDA-receptor coagonists in serum, plasma, and cerebrospinal fluid of schizophrenia patients: A meta-analysis of case-control studies.
MedLine Citation:
PMID:  23792047     Owner:  NLM     Status:  Publisher    
Serine and other amino acids that function as coagonists at the N-methyl-d-aspartate receptor (NMDAR) have been extensively investigated in schizophrenia (SCZ). However, studies comparing amino acid levels in body fluids of SCZ patients with healthy controls have yielded inconsistent results. We therefore conducted a meta-analysis (search: May 9, 2013) of serine, l-serine, d-serine, glycine, alanine, proline and aspartate levels in blood and cerebrospinal fluid (CSF) obtained from adult SCZ patients and healthy controls. Standardized differences of means (SDMs) were computed, and heterogeneity, subgroup, sensitivity, and publication bias analyses were conducted. Blood serine levels were found to be significantly higher in SCZ patients compared to healthy controls (SDM=0.280 (0.021-0.540), p=0.034; N=1671 subjects), whereas CSF serine, l-serine, d-serine, glycine, alanine, proline and aspartate levels did not differ. Stratification by sex suggested that the case-control difference in blood serine levels particularly applied to male subjects. These results provide support for blood serine level aberrations in SCZ patients and warrant further research to disentangle the involvement of serine with SCZ in both sexes.
Annelies Brouwer; Jurjen J Luykx; Loes van Boxmeer; Steven C Bakker; René S Kahn
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-18
Journal Detail:
Title:  Neuroscience and biobehavioral reviews     Volume:  -     ISSN:  1873-7528     ISO Abbreviation:  Neurosci Biobehav Rev     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-6-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806090     Medline TA:  Neurosci Biobehav Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht (UMCU), Utrecht, The Netherlands. Electronic address:
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