Document Detail

NMDA receptors in dopaminergic neurons are crucial for habit learning.
MedLine Citation:
PMID:  22196339     Owner:  NLM     Status:  MEDLINE    
Dopamine is crucial for habit learning. Activities of midbrain dopaminergic neurons are regulated by the cortical and subcortical signals among which glutamatergic afferents provide excitatory inputs. Cognitive implications of glutamatergic afferents in regulating and engaging dopamine signals during habit learning, however, remain unclear. Here, we show that mice with dopaminergic neuron-specific NMDAR1 deletion are impaired in a variety of habit-learning tasks, while normal in some other dopamine-modulated functions such as locomotor activities, goal-directed learning, and spatial reference memories. In vivo neural recording revealed that dopaminergic neurons in these mutant mice could still develop the cue-reward association responses; however, their conditioned response robustness was drastically blunted. Our results suggest that integration of glutamatergic inputs to DA neurons by NMDA receptors, likely by regulating associative activity patterns, is a crucial part of the cellular mechanism underpinning habit learning.
Lei Phillip Wang; Fei Li; Dong Wang; Kun Xie; Deheng Wang; Xiaoming Shen; Joe Z Tsien
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuron     Volume:  72     ISSN:  1097-4199     ISO Abbreviation:  Neuron     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-26     Completed Date:  2012-02-14     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1055-66     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Brain and Behavior Discovery Institute and Department of Neurology, Georgia Health Sciences University, Augusta, GA 30912, USA.
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MeSH Terms
Dopaminergic Neurons / physiology*
Learning / physiology*
Mice, Inbred C57BL
Mice, Transgenic
Psychomotor Performance / physiology*
Receptors, N-Methyl-D-Aspartate / physiology*
Grant Support
R01 AG034663-02/AG/NIA NIH HHS; R01 MH060236-12/MH/NIMH NIH HHS
Reg. No./Substance:
0/NMDA receptor A1; 0/Receptors, N-Methyl-D-Aspartate
Comment In:
Neuron. 2011 Dec 22;72(6):892-4   [PMID:  22196325 ]

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