| NMDA receptors in dopaminergic neurons are crucial for habit learning. | |
| | |
MedLine Citation:
|
PMID: 22196339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Dopamine is crucial for habit learning. Activities of midbrain dopaminergic neurons are regulated by the cortical and subcortical signals among which glutamatergic afferents provide excitatory inputs. Cognitive implications of glutamatergic afferents in regulating and engaging dopamine signals during habit learning, however, remain unclear. Here, we show that mice with dopaminergic neuron-specific NMDAR1 deletion are impaired in a variety of habit-learning tasks, while normal in some other dopamine-modulated functions such as locomotor activities, goal-directed learning, and spatial reference memories. In vivo neural recording revealed that dopaminergic neurons in these mutant mice could still develop the cue-reward association responses; however, their conditioned response robustness was drastically blunted. Our results suggest that integration of glutamatergic inputs to DA neurons by NMDA receptors, likely by regulating associative activity patterns, is a crucial part of the cellular mechanism underpinning habit learning. |
| | |
Authors:
|
Lei Phillip Wang; Fei Li; Dong Wang; Kun Xie; Deheng Wang; Xiaoming Shen; Joe Z Tsien |
Related Documents
:
|
19923289 - Correlations of neuronal and microvascular densities in murine cortex revealed by direc... 21544179 - Effect of honey bee venom on differentiation of cholinergic neurons. 15761949 - Applications of manganese-enhanced magnetic resonance imaging (memri) to image brain pl... 21640839 - Antidepressant medications reduce subcortical-cortical resting-state functional connect... 21280159 - Tracking stem cell differentiation in the setting of automated optogenetic stimulation. 20138449 - Comparative study of the sensitivity of adc value and t(2) relaxation time for early de... 23070049 - Munc13 genotype regulates secretory amyloid precursor protein processing via postsynapt... 9809299 - Effects of iontophoretic administration of acetylcholine to rabbit motor cortex neurons... 23419789 - Contributions of pitch and bandwidth to sound-induced enhancement of visual cortex exci... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Neuron Volume: 72 ISSN: 1097-4199 ISO Abbreviation: Neuron Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-26 Completed Date: 2012-02-14 Revised Date: 2013-02-20 |
Medline Journal Info:
|
Nlm Unique ID: 8809320 Medline TA: Neuron Country: United States |
Other Details:
|
Languages: eng Pagination: 1055-66 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Brain and Behavior Discovery Institute and Department of Neurology, Georgia Health Sciences University, Augusta, GA 30912, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Dopaminergic Neurons / physiology* Habits* Learning / physiology* Male Mice Mice, Inbred C57BL Mice, Transgenic Psychomotor Performance / physiology* Receptors, N-Methyl-D-Aspartate / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
R01 AG034663-02/AG/NIA NIH HHS; R01 MH060236-12/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/NMDA receptor A1; 0/Receptors, N-Methyl-D-Aspartate |
| Comments/Corrections | |
Comment In:
|
Neuron. 2011 Dec 22;72(6):892-4
[PMID:
22196325
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Functional specialization of seven mouse visual cortical areas.
Next Document: Multifocal Attention Filters Targets from Distracters within and beyond Primate MT Neurons' Receptiv...