Document Detail


NMDA receptor activation: two targets for two co-agonists.
MedLine Citation:
PMID:  23389661     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neuronal N-methyl-D-aspartate receptors (NMDARs) play a critical role in synaptic plasticity. Their activation requires not only binding of their ligand glutamate and membrane depolarization but also the presence of a co-agonist, glycine or D-serine. An increasing body of experimental evidence suggests that different populations of NMDARs could be gated by different co-agonists. Here we discuss how the spatial distribution of co-agonist sources and uptake mechanisms, together with diffusional properties of the synaptic environment, could shape NMDAR co-agonist supply and therefore NMDAR-dependent plasticity.
Authors:
Christian Henneberger; Lucie Bard; Claire King; Alistair Jennings; Dmitri A Rusakov
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-02-07
Journal Detail:
Title:  Neurochemical research     Volume:  38     ISSN:  1573-6903     ISO Abbreviation:  Neurochem. Res.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-14     Completed Date:  2013-12-24     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1156-62     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Transport System ASC / physiology
Animals
Glycine / metabolism*
Humans
Neuronal Plasticity / physiology
Receptors, N-Methyl-D-Aspartate / agonists*,  physiology*
Serine / metabolism*
Synapses / physiology
Grant Support
ID/Acronym/Agency:
G0802216//Medical Research Council; G0900613//Medical Research Council; //Medical Research Council; //Wellcome Trust
Chemical
Reg. No./Substance:
0/Amino Acid Transport System ASC; 0/Receptors, N-Methyl-D-Aspartate; 452VLY9402/Serine; TE7660XO1C/Glycine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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