Document Detail


NMDA and GABAB (KIR) conductances: the "perfect couple" for bistability.
MedLine Citation:
PMID:  23303922     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Networks that produce persistent firing in response to novel input patterns are thought to be important in working memory and other information storage functions. One possible mechanism for maintaining persistent firing is dendritic voltage bistability in which the depolarized state depends on the voltage dependence of the NMDA conductance at recurrent synapses. In previous models, the hyperpolarized state is dependent on voltage-independent conductances, including GABA(A). The interplay of these conductances leads to bistability, but its robustness is limited by the fact that the conductance ratio must be within a narrow range. The GABA(B) component of inhibitory transmission was not considered in previous analyses. Here, we show that the voltage dependence of the inwardly rectifying potassium (KIR) conductance activated by GABA(B) receptors adds substantial robustness to network simulations of bistability and the persistent firing that it underlies. The hyperpolarized state is robust because, at hyperpolarized potentials, the GABA(B)/KIR conductance is high and the NMDA conductance is low; the depolarized state is robust because, at depolarized potentials, the NMDA conductance is high and the GABA(B)/KIR conductance is low. Our results suggest that this complementary voltage dependence of GABA(B)/KIR and NMDA conductances makes them a "perfect couple" for producing voltage bistability.
Authors:
Honi Sanders; Michiel Berends; Guy Major; Mark S Goldman; John E Lisman
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  33     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-10     Completed Date:  2013-03-04     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  424-9     Citation Subset:  IM    
Affiliation:
Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254, USA.
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Computer Simulation
Electrophysiological Phenomena
G Protein-Coupled Inwardly-Rectifying Potassium Channels / genetics,  physiology*
Humans
Memory, Short-Term / physiology
Models, Neurological
Nerve Net / physiology
Neurons / physiology
Receptors, GABA-B / physiology*
Receptors, N-Methyl-D-Aspartate / physiology*
Synapses / physiology
Grant Support
ID/Acronym/Agency:
R01 DA027807/DA/NIDA NIH HHS; R01 MH069726/MH/NIMH NIH HHS; R01DA027807/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/G Protein-Coupled Inwardly-Rectifying Potassium Channels; 0/Receptors, GABA-B; 0/Receptors, N-Methyl-D-Aspartate
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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