Document Detail


Natural killer p46High expression defines a natural killer cell subset that is potentially involved in control of hepatitis C virus replication and modulation of liver fibrosis.
MedLine Citation:
PMID:  22532190     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSIONS: NKp46(High) expression defines a specific NK-cell subset that may be involved in both the suppression of HCV replication and HCV-associated liver damage underpinning the role of NK cells in the immunopathogenesis of HCV.
Authors:
Benjamin Krämer; Christian Körner; Moritz Kebschull; Andreas Glässner; Marianne Eisenhardt; Hans-Dieter Nischalke; Michael Alexander; Tilman Sauerbruch; Ulrich Spengler; Jacob Nattermann
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-31
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  56     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-05     Completed Date:  2013-01-17     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1201-13     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Association for the Study of Liver Diseases.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Biopsy, Needle
Case-Control Studies
Cells, Cultured
Cytotoxicity, Immunologic / genetics,  immunology
Disease Progression
Fatty Liver / genetics,  immunology,  physiopathology
Female
Flow Cytometry
Gene Expression Regulation, Viral
Hepacivirus / immunology*,  pathogenicity
Hepatic Stellate Cells / immunology,  physiology
Hepatitis C, Chronic / genetics,  immunology*,  physiopathology
Hepatitis, Autoimmune / genetics,  immunology,  physiopathology
Humans
Immunohistochemistry
Killer Cells, Natural / immunology,  physiology
Linear Models
Liver Cirrhosis / genetics,  immunology*,  physiopathology,  virology
Liver Function Tests
Male
Middle Aged
Natural Cytotoxicity Triggering Receptor 1 / genetics*,  metabolism
Natural Cytotoxicity Triggering Receptor 3 / genetics,  immunology
RNA, Viral / genetics
Sensitivity and Specificity
Statistics, Nonparametric
Virus Replication / genetics,  immunology*
Young Adult
Chemical
Reg. No./Substance:
0/Natural Cytotoxicity Triggering Receptor 1; 0/Natural Cytotoxicity Triggering Receptor 3; 0/RNA, Viral
Comments/Corrections
Comment In:
Hepatology. 2012 Oct;56(4):1197-200   [PMID:  22610395 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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