Document Detail

NKT cell subsets in infection and inflammation.
MedLine Citation:
PMID:  12527223     Owner:  NLM     Status:  MEDLINE    
We recently identified two stably expressed cell surface markers, IL-18R and ST2L, which are selectively expressed on T1/NK1 and T2/NK2 cells, respectively. Here we use these molecules in direct ex vivo analysis of PBMCs from patients with AIDS, psoriasis (PS) atherosclerosis and to show the importance of these markers as determinants of the functional dichotomy of lymphocyte subsets, in particular NKT. In a cohort of 22 HIV patients made up of a mixture of long term non-progressors, seroconvertors, progressors and asymptomatics, we found a clear NKT1 to NKT2 shift (P=0.001) in the HIV-infected individuals. We also show a predominance of NKT2 cells over NKT1 cells in the PBMCs of patients with mild to moderate PS (N=13, P=0.005) but not in atopic dermatitis or healthy controls. However, in patients (N=6) requiring surgery for aneurysm, a predominance of Type 1 (IL-18R(+)) NKT lymphocytes over NKT2 was detected among infiltrating lymphocytes isolated from atherosclerotic plaques. Our data therefore demonstrate that ST2L and IL-18R could serve as important determinants of the immune status of human diseases.
Woon Ling Chan; Nada Pejnovic; Tze Vun Liew; Christine A Lee; Richard Groves; Hamish Hamilton
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Immunology letters     Volume:  85     ISSN:  0165-2478     ISO Abbreviation:  Immunol. Lett.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-01-15     Completed Date:  2003-07-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910006     Medline TA:  Immunol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  159-63     Citation Subset:  IM    
Department of Biochemical Pharmacology, Queen Mary's School of Medicine, University of London, London, UK.
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MeSH Terms
Acquired Immunodeficiency Syndrome / immunology
Antigens, Differentiation, T-Lymphocyte / immunology*
Arteriosclerosis / immunology
Infection / immunology
Inflammation / immunology
Killer Cells, Natural / physiology*
Psoriasis / immunology
T-Lymphocyte Subsets / physiology*
Reg. No./Substance:
0/Antigens, Differentiation, T-Lymphocyte

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