Document Detail

NKG2D-RAE-1 receptor-ligand variation does not account for the NK cell defect in nonobese diabetic mice.
MedLine Citation:
PMID:  18981127     Owner:  NLM     Status:  MEDLINE    
NK cells from NOD mice induced with poly(I:C) in vivo exhibit low cytotoxicity against a range of target cells, but the genetic mechanisms controlling this defect are yet to be elucidated. Defects in the expression of NKG2D and its ligands, the RAE-1 molecules, have been hypothesized to contribute to the reduced NK function present in NOD mice. In this study, we show that segregation of the NK-mediated killing phenotype did not correlate with the NOD Raet1 haplotype and that the large alterations in NKG2D expression previously reported on NK cells expanded in vitro were not observed in primary, poly(I:C)-elicited NK cells in vivo. Additional studies indicate a complex genetic control of defective NOD NK cells including genes linked to the MHC and possibly those that are associated with an altered cytokine response to the TLR3-agonist poly(I:C).
Lisa M Maier; Sarah K Howlett; Kara M Rainbow; Jan Clark; Joanna M M Howson; John A Todd; Linda S Wicker
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  181     ISSN:  1550-6606     ISO Abbreviation:  J. Immunol.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-04     Completed Date:  2008-12-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7073-80     Citation Subset:  AIM; IM    
Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.
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MeSH Terms
Diabetes Mellitus, Type 1 / genetics*,  immunology*
Flow Cytometry
Interferon Inducers / immunology
Killer Cells, Natural / immunology*
Membrane Proteins / genetics*,  immunology
Mice, Inbred NOD
NK Cell Lectin-Like Receptor Subfamily K / genetics*,  immunology
Poly I-C / immunology
Reverse Transcriptase Polymerase Chain Reaction
Grant Support
061859//Wellcome Trust; 079895//Wellcome Trust
Reg. No./Substance:
0/Interferon Inducers; 0/Klrk1 protein, mouse; 0/Membrane Proteins; 0/NK Cell Lectin-Like Receptor Subfamily K; 24939-03-5/Poly I-C

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