Document Detail

NKCC1 and hypertension: Role in the regulation of vascular smooth muscle contractions and myogenic tone.
MedLine Citation:
PMID:  22713139     Owner:  NLM     Status:  In-Data-Review    
High-ceiling diuretics (HCD), known potent inhibitors of housekeeping Na(+),K(+),2Cl cotransporter (NKCC1) and renal-specific NKCC2, decrease [Cl(-)](i), hyperpolarize vascular smooth muscle cells (VSMC), and suppress contractions evoked by modest depolarization, phenylephrine, angiotensin II, and UTP. These actions are absent in nkcc1 (/) knock-out mice, indicating that HCD interact with NKCC1 rather than with other potential targets. These findings also suggest that VSMC-specific inhibitors of NKCC1 may be considered potential pharmacological therapeutic tools in treatment of hypertension. It should be underlined that side by side with attenuation of peripheral resistance and systemic blood pressure, HCD blocked myogenic tone (MT) in renal afferent arterioles. Keeping this in mind, attenuation of MT might be a mechanism underlying the prevalence of end-stage renal disease documented in hypertensive African-Americans with decreased NKCC1 activity and in hypertensive patients subjected to chronic HCD treatment. The role of NKCC1-mediated MT in protection of the brain, heart, and other encapsulated organs deserves further investigation.
Sergei N Orlov; Svetlana V Koltsova; Johanne Tremblay; Mikhail B Baskakov; Pavel Hamet
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of medicine     Volume:  44 Suppl 1     ISSN:  1365-2060     ISO Abbreviation:  Ann. Med.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8906388     Medline TA:  Ann Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  S111-8     Citation Subset:  IM    
Research Centre, Centre hospitalier de l'Université de Montréal (CRCHUM)-Technôpole Angus, and Department of Medicine, Université de Montréal, Montreal , Quebec , Canada.
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