Document Detail


NK cells: a double-edged sword in chronic hepatitis B virus infection.
MedLine Citation:
PMID:  23459859     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
There is natural enrichment of NK cells in the human liver and this intrahepatic predominance underscores their potential importance in the control of infections with hepatotropic viruses such as hepatitis B virus (HBV). The contribution of innate components during chronic HBV infection has been a relatively under-investigated area. However, recent data have highlighted that NK cells are capable of exerting antiviral and immunoregulatory functions whilst also contributing to the pathogenesis of liver injury via death receptor pathways. We will present an overview of current knowledge regarding the complex biology of NK cells in the context of their antiviral versus pathogenic role in chronic hepatitis B as a clinically relevant avenue for further investigation.
Authors:
Mala K Maini; Dimitra Peppa
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Publication Detail:
Type:  Journal Article     Date:  2013-03-01
Journal Detail:
Title:  Frontiers in immunology     Volume:  4     ISSN:  1664-3224     ISO Abbreviation:  Front Immunol     Publication Date:  2013  
Date Detail:
Created Date:  2013-03-05     Completed Date:  2013-03-06     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101560960     Medline TA:  Front Immunol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  57     Citation Subset:  -    
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
G0902009//Medical Research Council
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