Document Detail


NK cell-mediated cytotoxicity modulation by A(2) adenosine receptor agonist in different mammalian species.
MedLine Citation:
PMID:  19826926     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adenosines, endogenous purine nucleosides, appear in the extracellular space under metabolically stressful conditions associated with ischemia, inflammation, and cell damage. Their activity on innate immunity is prevalently inhibitory and can develop both in infectious and neoplastic diseases. During cancer development, tumor cells that release high concentrations of adenosines can impair the function of tumor-infiltrating lymphocytes and assist tumor growth by neo-angiogenesis. We evaluated the influence of A(2) adenosine receptor (A(2)AR) agonist on cytotoxic-cell response comparing human with other mammalian species (rodents, pigs, goats), both in healthy and in cancer conditions. The A(2)AR agonist developed dose-dependent inhibition of the cytotoxic activity of immune effector cells in all studied species. However, variability of the response was observed in relation to the species and the target cells that were used. Altogether, our data indicate that the A(2)AR plays a central role in adenosine-mediated inhibition of immune response to tumors.
Authors:
M Kuldová; J Svoboda; F Kovárů; L Vannucci; H Kovárů; A Fiserová
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-14
Journal Detail:
Title:  Folia microbiologica     Volume:  54     ISSN:  1874-9356     ISO Abbreviation:  Folia Microbiol. (Praha)     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-14     Completed Date:  2009-12-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376757     Medline TA:  Folia Microbiol (Praha)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  364-8     Citation Subset:  IM    
Affiliation:
Department of Immunology and Gnotobiology, Institute of Microbiology, v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic.
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MeSH Terms
Descriptor/Qualifier:
Adenosine / analogs & derivatives*,  immunology,  pharmacology
Animals
Cells, Cultured
Cytotoxicity, Immunologic / drug effects*
Female
Goats
Humans
Killer Cells, Natural / drug effects,  immunology*
Male
Mice
Mice, Inbred C57BL
Neoplasms / immunology
Rats
Rats, Wistar
Receptors, Adenosine A2 / agonists*,  immunology
Rodentia
Swine
Chemical
Reg. No./Substance:
0/Receptors, Adenosine A2; 50908-62-8/N-cyclopropyl adenosine-5'-carboxamide; 58-61-7/Adenosine

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