| NK-cell lymphoma with nodal presentation and expression of cutaneous lymphocyte-associated antigen. | |
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MedLine Citation:
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PMID: 19628338 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nasal and nasal-type NK/T-cell lymphomas are predominantly extranodal tumors with a specific immunophenotype and a strong association with EBV. The cutaneous lymphocyte-associated antigen (CLA) is the homing receptor for skin-homing T cells and NK cells. In the literature, the prognostic impact of CLA expression in primary cutaneous T-cell lymphomas and nasal NK-cell lymphomas is contradictory. We present 2 non-nasal NK-cell lymphomas with nodal presentation. Both tumors showed the phenotype of CD3+ (cytoplasmic), CD5-, CD7-, CD16+, CD56+, cytotoxic molecules+, EBV+ (by in situ hybridization), and CLA+. They were polyclonal for T-cell receptor gamma chain gene rearrangement, indicating an NK cell lineage. The aggressive course in these two patients suggested that in nasal and nasal-type NK-cell lymphomas, CLA expression might be an indicator of poor prognosis. More studies are needed to elucidate the prognostic impact of CLA expression in T cell and NK-cell lymphomas. |
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Authors:
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Sheng-Tsung Chang; Yung-Liang Liao; Shu-Hui Lin; Shih-Sung Chuang |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-07-22 |
Journal Detail:
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Title: Pathology, research and practice Volume: 206 ISSN: 1618-0631 ISO Abbreviation: Pathol. Res. Pract. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-15 Completed Date: 2010-11-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806109 Medline TA: Pathol Res Pract Country: Germany |
Other Details:
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Languages: eng Pagination: 463-6 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier GmbH. All rights reserved. |
Affiliation:
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Department of Pathology, Chi-Mei Medical Center, Tainan 710, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, Differentiation, T-Lymphocyte
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biosynthesis* Antineoplastic Combined Chemotherapy Protocols / therapeutic use Epstein-Barr Virus Infections / complications Fatal Outcome Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor Humans Immunophenotyping Killer Cells, Natural / metabolism, pathology* Lymph Nodes / pathology* Lymphoma, T-Cell / genetics, metabolism, pathology* Male Membrane Glycoproteins / biosynthesis* Middle Aged Prognosis Tumor Markers, Biological / analysis |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Differentiation, T-Lymphocyte; 0/CTAGE1 protein, human; 0/Membrane Glycoproteins; 0/Tumor Markers, Biological |
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