Document Detail

NK-cell lymphoma with nodal presentation and expression of cutaneous lymphocyte-associated antigen.
MedLine Citation:
PMID:  19628338     Owner:  NLM     Status:  MEDLINE    
Nasal and nasal-type NK/T-cell lymphomas are predominantly extranodal tumors with a specific immunophenotype and a strong association with EBV. The cutaneous lymphocyte-associated antigen (CLA) is the homing receptor for skin-homing T cells and NK cells. In the literature, the prognostic impact of CLA expression in primary cutaneous T-cell lymphomas and nasal NK-cell lymphomas is contradictory. We present 2 non-nasal NK-cell lymphomas with nodal presentation. Both tumors showed the phenotype of CD3+ (cytoplasmic), CD5-, CD7-, CD16+, CD56+, cytotoxic molecules+, EBV+ (by in situ hybridization), and CLA+. They were polyclonal for T-cell receptor gamma chain gene rearrangement, indicating an NK cell lineage. The aggressive course in these two patients suggested that in nasal and nasal-type NK-cell lymphomas, CLA expression might be an indicator of poor prognosis. More studies are needed to elucidate the prognostic impact of CLA expression in T cell and NK-cell lymphomas.
Sheng-Tsung Chang; Yung-Liang Liao; Shu-Hui Lin; Shih-Sung Chuang
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-07-22
Journal Detail:
Title:  Pathology, research and practice     Volume:  206     ISSN:  1618-0631     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-15     Completed Date:  2010-11-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  463-6     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier GmbH. All rights reserved.
Department of Pathology, Chi-Mei Medical Center, Tainan 710, Taiwan.
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MeSH Terms
Antigens, Differentiation, T-Lymphocyte / biosynthesis*
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Epstein-Barr Virus Infections / complications
Fatal Outcome
Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
Killer Cells, Natural / metabolism,  pathology*
Lymph Nodes / pathology*
Lymphoma, T-Cell / genetics,  metabolism,  pathology*
Membrane Glycoproteins / biosynthesis*
Middle Aged
Tumor Markers, Biological / analysis
Reg. No./Substance:
0/Antigens, Differentiation, T-Lymphocyte; 0/CTAGE1 protein, human; 0/Membrane Glycoproteins; 0/Tumor Markers, Biological

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