| NK cell deficiency predisposes to viral-induced Th2-type allergic inflammation via epithelial-derived IL-25. | |
| | |
MedLine Citation:
|
PMID: 20855881 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Severe respiratory syncytial virus (RSV) infection has long been associated with an increased risk for the development of childhood asthma and exacerbations of this disorder. Despite much research into the induction of Th2 responses by allergens and helminths, the factors associated with viral infection that predispose to Th2-regulated asthma remain unknown. Recently, clinical studies have shown reduced numbers of NK cells in infants suffering from a severe RSV infection. Here we demonstrate that NK cell deficiency during primary RSV infection of BALB/c mice results in the suppression of IFN-γ production and the development of an RSV-specific Th2 response and subsequent allergic lung disease. The outgrowth of the Th2 responses was dependent on airway epithelial cell-derived IL-25, which induced the upregulation of the notch ligand Jagged1 on dendritic cells. This study identifies a novel pathway underlying viral-driven Th2 responses that may have functional relevance to viral-associated asthma. |
| | |
Authors:
|
Gerard E Kaiko; Simon Phipps; Pornpimon Angkasekwinai; Chen Dong; Paul S Foster |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-20 |
Journal Detail:
|
Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 185 ISSN: 1550-6606 ISO Abbreviation: J. Immunol. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-06 Completed Date: 2010-11-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
|
Languages: eng Pagination: 4681-90 Citation Subset: AIM; IM |
Affiliation:
|
Centre for Asthma and Respiratory Diseases, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Newcastle, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Asthma / immunology*, metabolism, virology Bronchoalveolar Lavage Calcium-Binding Proteins / biosynthesis, immunology Cell Separation Dendritic Cells / immunology, metabolism Enzyme-Linked Immunosorbent Assay Epithelial Cells / immunology, metabolism Flow Cytometry Hypersensitivity / immunology, metabolism, virology Immunohistochemistry Inflammation / immunology, metabolism, virology Intercellular Signaling Peptides and Proteins / biosynthesis, immunology Interleukins / biosynthesis, immunology* Killer Cells, Natural / immunology*, metabolism Male Membrane Proteins / biosynthesis, immunology Mice Mice, Inbred BALB C Respiratory Mucosa / immunology, metabolism Respiratory Syncytial Virus Infections / immunology*, metabolism Reverse Transcriptase Polymerase Chain Reaction Th2 Cells / immunology*, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Calcium-Binding Proteins; 0/D17Wsu104e protein, mouse; 0/Intercellular Signaling Peptides and Proteins; 0/Interleukins; 0/Membrane Proteins; 134324-36-0/Serrate proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cutting edge: TCR ligation triggers digital activation of NF-kappaB.
Next Document: Gender differences in 1,25 dihydroxyvitamin D3 immunomodulatory effects in multiple sclerosis patien...