Document Detail

NHANES III: influence of race on GFR thresholds and detection of metabolic abnormalities.
MedLine Citation:
PMID:  17656476     Owner:  NLM     Status:  MEDLINE    
Whether the creatinine-based glomerular filtration rate (GFR) thresholds used to define chronic kidney disease (CKD) identify metabolic abnormalities similarly in minority and nonminority populations is unknown. We addressed this question among adult participants in the Third National Health and Nutrition Examination Survey (NHANES III) (n = 15,837). GFR was estimated from serum creatinine values and metabolic abnormalities were defined by 5th or 95th percentile values. After adjustment for age, demographic characteristics, and GFR, black participants were significantly more likely than white participants to have abnormal levels of systolic and diastolic blood pressure, hemoglobin, phosphorus, and uric acid. Hispanic subjects were significantly more likely to have abnormal levels of systolic blood pressure, hemoglobin, bicarbonate, and phosphorus. Among participants with GFR < 60 mL/min per 1.73 m(2), black participants were significantly more likely to have abnormal levels of systolic and diastolic blood pressure, hemoglobin, and uric acid; Hispanic subjects were significantly more likely to have abnormal systolic blood pressure levels. Metabolic abnormalities were more common in minority populations, and low GFR appeared to have a multiplicative effect. Defining CKD using a single GFR threshold may be disadvantageous for minority populations because metabolic abnormalities are present at higher levels of GFR.
Robert N Foley; Changchun Wang; Areef Ishani; Allan J Collins
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-07-26
Journal Detail:
Title:  Journal of the American Society of Nephrology : JASN     Volume:  18     ISSN:  1046-6673     ISO Abbreviation:  J. Am. Soc. Nephrol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-29     Completed Date:  2007-11-13     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  9013836     Medline TA:  J Am Soc Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2575-82     Citation Subset:  IM    
United States Renal Data System Coordinating Center, Minneapolis, MN 55404, USA.
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MeSH Terms
African Continental Ancestry Group
Bicarbonates / blood
Blood Pressure
Chronic Disease
Continental Population Groups*
Creatinine / blood
Differential Threshold
European Continental Ancestry Group
Glomerular Filtration Rate*
Hemoglobins / metabolism
Hispanic Americans
Kidney Diseases / blood,  diagnosis*,  physiopathology*
Middle Aged
Nutrition Surveys*
Phosphorus / blood
Uric Acid / blood
Grant Support
Reg. No./Substance:
0/Bicarbonates; 0/Hemoglobins; 60-27-5/Creatinine; 69-93-2/Uric Acid; 7723-14-0/Phosphorus

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