| NH-1,2,3-Triazole-based Inhibitors of the VIM-2 Metallo-beta-Lactamase: Synthesis and Structure-Activity Studies. | |
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MedLine Citation:
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PMID: 20625539 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Metallo-ss-lactamases (MBL) are an emerging cause of bacterial resistance to antibiotic treatment. The VIM-2 ss-lactamase is the most commonly encountered MBL in clinical isolates worldwide. Described here are potent and selective small molecule inhibitors of VIM-2 containing the arylsulfonyl-NH-1,2,3-triazole chemotype that potentiate the efficacy of the ss-lactam, imipenem, in E. coli. |
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Authors:
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Timo Weide; S Adrian Saldanha; Dmitriy Minond; Timothy P Spicer; Joseph R Fotsing; Michael Spaargaren; Jean-Marie Frère; Carine Bebrone; K Barry Sharpless; Peter S Hodder; Valery V Fokin |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: ACS medicinal chemistry letters Volume: 1 ISSN: 1948-5875 ISO Abbreviation: - Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-7-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101521073 Medline TA: ACS Med Chem Lett Country: - |
Other Details:
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Languages: ENG Pagination: 150-154 Citation Subset: - |
Affiliation:
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Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla CA 92037, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R21 NS059451-01//NINDS NIH HHS; R21 NS059451-01S1//NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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