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NGFR (p75) Expression in Cutaneous Scars; Further Evidence for a Potential Pitfall in Evaluation of Reexcision Scars of Cutaneous Neoplasms, in Particular Desmoplastic Melanoma.
MedLine Citation:
PMID:  21178583     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Desmoplastic melanoma is a rare variant of malignant melanoma composed of spindle cells in a collagenous matrix. The antibody against NGFR (low affinity nerve growth factor receptor, also known as p75) stains cells of desmoplastic melanoma with high sensitivity; however, the specificity of this marker is not well established. Although there are established histologic criteria for recognition of desmoplastic melanoma, the evaluation of residual disease in cutaneous reexcision scars can be challenging. If residual spindle cells in scar are sufficiently atypical and NGFR positive, their presence could be interpreted as residual desmoplastic melanoma. In this study, we reevaluated the use of antibody against NGFR to detect residual disease in reexcision specimens of melanocytic neoplasms as the previously published works are contradictory. Our data indicate that anti-NGFR antibody stains many cells in the scar, some of which seem to be myofibroblasts, nerve twigs, and Schwann cells. Our findings further suggest that NGFR is not a suitable marker to evaluate reexcision scars for desmoplastic melanoma, especially as a sole marker, as its specificity is low.
Authors:
Sarah Otaibi; Drazen M Jukic; Laura Drogowski; Jag Bhawan; Arash Radfar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  33     ISSN:  1533-0311     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  65-71     Citation Subset:  IM    
Affiliation:
From the *Lake Erie College of Osteopathic Medicine and School of Pharmacy, Erie, PA; †Department of Dermatology, Dermatopathology Unit; ‡Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA; and §Department of Dermatology, Skin Pathology Laboratory, Boston University School of Medicine, Boston, MA.
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