Document Detail

NGF-induced motoneuron cell death depends on the genetic background and motoneuron sub-type.
MedLine Citation:
PMID:  10841360     Owner:  NLM     Status:  MEDLINE    
Nerve growth factor (NGF) promotes the survival of several neuronal populations, but recently it has also been shown to induce neuronal cell death. Here we report the effects of NGF on lesioned motoneurons. We have analyzed facial and sciatic motoneurons in newborn and adult BALB/c and C57BL/6 mice, in addition to mice deficient in the low-affinity p75 receptor for the neurotrophins (p75NTR). NGF application did not alter survival of lesioned facial motoneurons in any of the strains examined independent of the age of the animals. Only in the adult C57BL/6 mouse strain where the sciatic nerve had been crushed prior to factor application did NGF induce cell death of axotomized sciatic motoneurons. Our results illustrate the importance of the genetic background and the motoneuron sub-type in studies related to cell death and survival of motoneurons in relation to NGF and p75NTR.
J Terrado; D Monnier; D Perrelet; Y Sagot; L Mattenberger; B King; A C Kato
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  11     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-09-06     Completed Date:  2000-09-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1473-7     Citation Subset:  IM    
Department APSIC, Faculty of Medicine, University of Geneva, Centre Medical Universitaire, Switzerland.
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MeSH Terms
Blotting, Western
Cell Death / drug effects*
Cell Survival / drug effects
Facial Nerve / cytology*
Mice, Inbred BALB C
Mice, Inbred C57BL
Motor Neurons / chemistry,  cytology*,  drug effects
Nerve Crush
Nerve Growth Factor / pharmacology*
Receptor, Nerve Growth Factor / analysis,  metabolism
Sciatic Nerve / cytology*
Species Specificity
Reg. No./Substance:
0/Receptor, Nerve Growth Factor; 9061-61-4/Nerve Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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