Document Detail


The NG2 chondroitin sulfate proteoglycan: a multifunctional proteoglycan associated with immature cells.
MedLine Citation:
PMID:  9117258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this review, we discuss the properties of the NG2 chondroitin sulfate proteoglycan, a structurally unique, integral membrane proteoglycan that is found on the surfaces of several different types of immature cells. NG2 is associated with multipotential glial precursor cells (O2A progenitor cells), chondroblasts of the developing cartilage, brain capillary endothelial cells, aortic smooth muscle cells, skeletal myoblasts and human melanoma cells. One common feature of these diverse cell types is that they retain the ability to divide throughout the life of the organism. The NG2 proteoglycan is a multifunctional protein; in vitro studies have shown that NG2 binds type VI collagen, interacts with and modulates the activity of the platelet-derived growth factor-alpha receptor, and inhibits neurite outgrowth. These functional properties are analogous to those of other proteoglycans such as syndecan, betaglycan, and neurocan, suggesting that structurally divergent proteoglycans can carry out similar functions within the organism.
Authors:
J M Levine; A Nishiyama
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Perspectives on developmental neurobiology     Volume:  3     ISSN:  1064-0517     ISO Abbreviation:  Perspect Dev Neurobiol     Publication Date:  1996  
Date Detail:
Created Date:  1997-04-24     Completed Date:  1997-04-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9417971     Medline TA:  Perspect Dev Neurobiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  245-59     Citation Subset:  IM    
Affiliation:
Department of Neurobiology and Behavior, State University of New York at Stony Brook 11794, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens / chemistry,  metabolism,  physiology*
Cell Aging
Humans
Proteoglycans / chemistry,  metabolism,  physiology*
Tissue Distribution
Grant Support
ID/Acronym/Agency:
NS 21198/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Antigens; 0/Proteoglycans; 0/chondroitin sulfate proteoglycan 4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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