Document Detail

The NG2 chondroitin sulfate proteoglycan: a multifunctional proteoglycan associated with immature cells.
MedLine Citation:
PMID:  9117258     Owner:  NLM     Status:  MEDLINE    
In this review, we discuss the properties of the NG2 chondroitin sulfate proteoglycan, a structurally unique, integral membrane proteoglycan that is found on the surfaces of several different types of immature cells. NG2 is associated with multipotential glial precursor cells (O2A progenitor cells), chondroblasts of the developing cartilage, brain capillary endothelial cells, aortic smooth muscle cells, skeletal myoblasts and human melanoma cells. One common feature of these diverse cell types is that they retain the ability to divide throughout the life of the organism. The NG2 proteoglycan is a multifunctional protein; in vitro studies have shown that NG2 binds type VI collagen, interacts with and modulates the activity of the platelet-derived growth factor-alpha receptor, and inhibits neurite outgrowth. These functional properties are analogous to those of other proteoglycans such as syndecan, betaglycan, and neurocan, suggesting that structurally divergent proteoglycans can carry out similar functions within the organism.
J M Levine; A Nishiyama
Related Documents :
20644508 - Isolation of human umbilical arterial smooth muscle cells (huasmc).
9471998 - Myogenic conversion of nih3t3 cells by exogenous myod family members: dissociation of t...
18092958 - Cd34-positive interstitial cells of the human detrusor.
7677178 - Active proliferation of different cell types, including lymphocytes, in human atheroscl...
22024918 - Do neuroendocrine cells come up large in small cell lung cancer?
22798368 - Proteomic analysis of survival of rhodococcus jostii rha1 during carbon starvation.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Perspectives on developmental neurobiology     Volume:  3     ISSN:  1064-0517     ISO Abbreviation:  Perspect Dev Neurobiol     Publication Date:  1996  
Date Detail:
Created Date:  1997-04-24     Completed Date:  1997-04-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9417971     Medline TA:  Perspect Dev Neurobiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  245-59     Citation Subset:  IM    
Department of Neurobiology and Behavior, State University of New York at Stony Brook 11794, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antigens / chemistry,  metabolism,  physiology*
Cell Aging
Proteoglycans / chemistry,  metabolism,  physiology*
Tissue Distribution
Grant Support
Reg. No./Substance:
0/Antigens; 0/Proteoglycans; 0/chondroitin sulfate proteoglycan 4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Characteristics of peripheral blood progenitor cells frozen after 24 hours of liquid storage.
Next Document:  Versican.