| NFκB and ubiquitination: partners in disarming RIPK1-mediated cell death. | |
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MedLine Citation:
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PMID: 22477525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mechanisms regulating cell survival and thus its corollary, cell death, have been intensively studied over the last two decades. Recent studies have shed new light into how non-degradative ubiquitination of the kinase RIPK1 is critical in determining this cell fate. In this review, we summarize recent findings on how ubiquitination of RIPK1 constitutes a survival signal through both NFκB-independent and NFκB-dependent mechanisms. However, in the absence of ubiquitination, RIPK1 becomes a death-signaling molecule capable of engaging both the caspase-dependent apoptosis machinery and the recently described RIPK3-dependent necroptosis machinery. Another layer of complexity is now emerging in that components of the ubiquitin-modifying machinery are themselves regulated by proteolytic processing. This survival/death regulatory mechanism has been best analyzed in the context of TNF receptor signaling, but it is likely that principles learned from TNFR may be applicable to other immune receptors including the antigen and Toll-like receptors. |
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Authors:
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Marie Anne O'Donnell; Adrian T Ting |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Immunologic research Volume: 54 ISSN: 1559-0755 ISO Abbreviation: Immunol. Res. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-10-17 Completed Date: 2013-03-07 Revised Date: 2013-05-08 |
Medline Journal Info:
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Nlm Unique ID: 8611087 Medline TA: Immunol Res Country: United States |
Other Details:
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Languages: eng Pagination: 214-26 Citation Subset: IM |
Affiliation:
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Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA. marie.a.odonnell@mssm.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caspase 8 / metabolism Cell Death / physiology* Cysteine Endopeptidases / metabolism Humans NF-kappa B / metabolism* Receptor-Interacting Protein Serine-Threonine Kinases / metabolism* Ubiquitination |
| Grant Support | |
ID/Acronym/Agency:
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AI052417/AI/NIAID NIH HHS; R01 AI052417/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/NF-kappa B; EC 2.7.11.1/RIPK1 protein, human; EC 2.7.11.1/Receptor-Interacting Protein Serine-Threonine Kinases; EC 3.4.22.-/Caspase 8; EC 3.4.22.-/Cysteine Endopeptidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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