| NFATc2 Ser170 phosphorylation marks mitosis in development and ES cells. | |
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MedLine Citation:
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PMID: 19395856 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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NFATc2, also known as NFAT1 or NFATp, is a member of NFAT (calcineurin-dependent nuclear factor of activated T cells) family of transcription factors. As one of major targets for immunosuppressive drugs, NFATc2 has been studied largely in the context of T cell activation and proliferation. Recent evidence suggested that it has a broader role in both immune and non-immune systems in regulating cell cycle progression. Using a monoclonal antibody developed specifically against phospho-serine 170 (p-Ser170) of NFATc2, we show here that this phosphorylation marks the M phase of cell cycle both during embryonic development and in cultured fibroblast and ES cells. |
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Authors:
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Cantas Alev; Yuping Wu; Fumie Nakazawa; Takayuki Asahara; Guojun Sheng |
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Publication Detail:
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Type: Letter Date: 2009-06-13 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 8 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-18 Completed Date: 2009-07-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 1803-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Antibodies, Monoclonal / immunology, metabolism Biological Markers / metabolism Cell Cycle Cell Division Embryonic Stem Cells / physiology* Humans Mitosis* Molecular Sequence Data NFATC Transcription Factors / immunology, metabolism* Phosphorylation T-Lymphocytes / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Biological Markers; 0/NFATC Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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