| NF-kappaB: a potential target for cancer chemoprevention and therapy. | |
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MedLine Citation:
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PMID: 17981768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nuclear factor-kappaB pathway plays important roles in the control of cell proliferation, differentiation, apoptosis, inflammation, stress response, cell signaling transduction, and other physiological processes. Because the disorder of these physiological processes has been linked with the onset of cancers, NF-kappaB has been described as a major culprit in cancer. Experimental in vitro and in vivo studies have shown that down-regulation of NF-kappaB activity by natural and synthetic NF-kappaB inhibitors suppresses the development of carcinogen-induced tumors, inhibits the growth of cancer cells, and induces apoptosis with alternation of gene expression which is critical for the control of carcinogenesis and cancer cell survival. Moreover, recent studies indicate that the effects of conventional cancer therapeutics could be enhanced by natural and synthetic NF-kappaB inhibitors, suggesting that down-regulation of NF-kappaB could sensitize cancer cells to conventional therapeutics. Therefore, targeting NF-kappaB is a novel preventive and therapeutic strategy against human cancers. In this brief review article, we will summarize the state of our knowledge for the role of NF-kappaB in relation to cancer prevention and therapy. |
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Authors:
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Fazlul H Sarkar; Yiwei Li |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2008-01-01 |
Journal Detail:
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Title: Frontiers in bioscience : a journal and virtual library Volume: 13 ISSN: 1093-4715 ISO Abbreviation: Front. Biosci. Publication Date: 2008 |
Date Detail:
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Created Date: 2007-11-05 Completed Date: 2007-12-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709506 Medline TA: Front Biosci Country: United States |
Other Details:
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Languages: eng Pagination: 2950-9 Citation Subset: IM |
Affiliation:
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Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA. fsarkar@med.wayne.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticarcinogenic Agents / pharmacology Gene Expression Regulation, Neoplastic* Humans Hydrogen Peroxide / pharmacology Isoflavones / chemistry Models, Biological NF-kappa B / metabolism* Neoplasms / metabolism*, prevention & control*, therapy* Oxidative Stress |
| Grant Support | |
ID/Acronym/Agency:
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5P20-CA101963/CA/NCI NIH HHS; 5R01CA083695/CA/NCI NIH HHS; 5R01CA101870/CA/NCI NIH HHS; 5R01CA108535/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anticarcinogenic Agents; 0/Isoflavones; 0/NF-kappa B; 7722-84-1/Hydrogen Peroxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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