| NF-kappa B activation in airways modulates allergic inflammation but not hyperresponsiveness. | |
| | |
MedLine Citation:
|
PMID: 15557197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Airways display robust NF-kappaB activation and represent targets for anti-inflammatory asthma therapies, but the functional importance of NF-kappaB activation in airway epithelium remains enigmatic. Therefore, transgenic mice were created in which NF-kappaB activation is repressed specifically in airways (CC10-IkappaBalpha(SR) mice). In response to inhaled Ag, transgenic mice demonstrated significantly ameliorated inflammation, reduced levels of chemokines, T cell cytokines, mucus cell metaplasia, and circulating IgE compared with littermate controls. Despite these findings, Ag-driven airways hyperresponsiveness was not attenuated in CC10-IkappaBalpha(SR) mice. This study clearly demonstrates that airway epithelial NF-kappaB activation orchestrates Ag-induced inflammation and subsequent adaptive immune responses, but does not contribute to airways hyperresponsiveness, the cardinal feature that underlies asthma. |
| | |
Authors:
|
Matthew E Poynter; Roy Cloots; Tiest van Woerkom; Kelly J Butnor; Pamela Vacek; Douglas J Taatjes; Charles G Irvin; Yvonne M W Janssen-Heininger |
Related Documents
:
|
17960347 - Chronic inflammation in the cystic fibrosis lung: alterations in inter- and intracellul... 19049817 - Anti-asthmatic effect of marine red alga (laurencia undulata) polyphenolic extracts in ... 10217547 - Effects of dexamethasone on airway hyper-responsiveness to the adenosine a1 receptor ag... 17295217 - Extracellular nucleotides regulate ccl20 release from human primary airway epithelial c... 9206997 - Resistance to fas-mediated apoptosis of peripheral t cells in human t lymphocyte virus ... 15140777 - High production of proinflammatory and th1 cytokines by dendritic cells from patients w... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 173 ISSN: 0022-1767 ISO Abbreviation: J. Immunol. Publication Date: 2004 Dec |
Date Detail:
|
Created Date: 2004-11-23 Completed Date: 2005-01-14 Revised Date: 2010-09-20 |
Medline Journal Info:
|
Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
|
Languages: eng Pagination: 7003-9 Citation Subset: AIM; IM |
Affiliation:
|
Vermont Lung Center and the Department of Medicine, Division of Pulmonary and Critical Care, University of Vermont, Burlington, VT 05405, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Allergens
/
administration & dosage,
immunology Animals Antibody Specificity / genetics Bronchial Hyperreactivity / genetics, immunology*, pathology* Chemokines / antagonists & inhibitors, biosynthesis Cytokines / antagonists & inhibitors, biosynthesis I-kappa B Proteins / genetics Immunoglobulin E / biosynthesis Inflammation / genetics, immunology, prevention & control Inflammation Mediators / antagonists & inhibitors, metabolism, physiology* Lung / immunology, metabolism*, pathology* Mice Mice, Inbred BALB C Mice, Transgenic Mucus / secretion NF-kappa B / antagonists & inhibitors, metabolism, physiology* Ovalbumin / administration & dosage, immunology Respiratory Hypersensitivity / genetics, immunology*, pathology*, prevention & control Respiratory Mucosa / immunology, metabolism, pathology T-Lymphocyte Subsets / immunology, metabolism |
| Grant Support | |
ID/Acronym/Agency:
|
1 P20 RR16462/RR/NCRR NIH HHS; K22 ES011652/ES/NIEHS NIH HHS; P01-HL-67004/HL/NHLBI NIH HHS; P20 RR015557-010002/RR/NCRR NIH HHS; P20 RR15557/RR/NCRR NIH HHS; R01 HL060014-01A1/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Allergens; 0/Chemokines; 0/Cytokines; 0/I-kappa B Proteins; 0/Inflammation Mediators; 0/NF-kappa B; 139874-52-5/NF-kappaB inhibitor alpha; 37341-29-0/Immunoglobulin E; 9006-59-1/Ovalbumin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes...
Next Document: Inhibition of fractalkine ameliorates murine collagen-induced arthritis.