| NF-κB and Mucosal Homeostasis. | |
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MedLine Citation:
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PMID: 20838961 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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NF-κB is well characterized as a primary mediator of inflammatory responses during infection and immune reactions, but it has recently become evident that NF-κB also mediates a potent cytoprotective, homeostatic function under basal conditions. This role is especially evident in the mammalian intestine, which is challenged not only with a range of microbial pathogens, but is also in constant contact with potent proinflammatory commensal bacteria and their products. Present data lead to the overall conclusion that antiapoptotic actions of NF-κB in intestinal epithelial cells dominate tissue responses to many acute inflammatory and injurious challenges, whereas proinflammatory and cell survival functions of NF-κB in macrophages and T cells govern chronic intestinal inflammation. This review focuses on the protective and homeostatic functions of NF-κB, and the importance of NF-κB in determining host-microbe interactions in the intestinal tract. |
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Authors:
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Lars Eckmann; Andrew S Neish |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current topics in microbiology and immunology Volume: 349 ISSN: 0070-217X ISO Abbreviation: Curr. Top. Microbiol. Immunol. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-04-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0110513 Medline TA: Curr Top Microbiol Immunol Country: Germany |
Other Details:
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Languages: eng Pagination: 145-58 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA, 92093-0063, USA, leckmann@ucsd.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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