| NF-M trans-activates the human DNA topoisomerase II alpha promoter independently of c-Myb in HL-60 cells. | |
MedLine Citation:
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PMID: 9379678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Identifying transcriptional regulators of DNA topoisomerase II alpha (topo II alpha) is essential to decipher the mechanisms underlying leukemia cell resistance to topo II-directed antitumor drugs. We have previously reported that the proto-oncogene transcription factor c-Myb transactivates the topo II alpha promoter in several hematopoietic cell lines. Currently, we investigate whether NF-M, a C/EBP beta family member, cooperates with c-Myb in activating topo II alpha transcription. Although NF-M is the most efficacious trans-activator of topo II alpha that we have examined (approximately 38-fold over basal), NF-M does not appear to be involved in the endogenous transcriptional regulation of topo II alpha. Interestingly, we report that the sodium butyrate-dependent induction of the topo II alpha promoter observed previously appears to be mediated by c-Myb, independent of NF-M. |
Authors:
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T L Brandt; D J Kroll |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Leukemia research Volume: 21 ISSN: 0145-2126 ISO Abbreviation: Leuk. Res. Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-11-12 Completed Date: 1997-11-12 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 711-20 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Sciences, University of Colorado School of Pharmacy, Denver, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, Neoplasm CCAAT-Enhancer-Binding Proteins COS Cells DNA Topoisomerases, Type II / genetics* DNA Topoisomerases, Type II, Eukaryotic* DNA-Binding Proteins / pharmacology* Dose-Response Relationship, Drug HL-60 Cells Hela Cells Humans Isoenzymes / genetics* Nuclear Proteins / pharmacology* Promoter Regions, Genetic Transcription Factors Transcriptional Activation* |
| Grant Support | |
ID/Acronym/Agency:
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GM50381/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Neoplasm; 0/CCAAT-Enhancer-Binding Proteins; 0/DNA-Binding Proteins; 0/Isoenzymes; 0/Nuclear Proteins; 0/Transcription Factors; EC 5.99.1.-/DNA Topoisomerases, Type II, Eukaryotic; EC 5.99.1.3/DNA Topoisomerases, Type II; EC 5.99.1.3/DNA topoisomerase II alpha |
| Comments/Corrections | |
Comment In:
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Leuk Res. 1997 Nov-Dec;21(11-12):1033-6
[PMID:
9444936
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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