| NF-κB and Innate Immunity. | |
| | |
MedLine Citation:
|
PMID: 20848362 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Members of the NF-κB transcription factor family play a critical role in the development of innate immunity. Upon recognition of pathogen infections or tissue damage, the NF-κB pathway is strongly activated by cellular pattern recognition receptors, including Toll-like receptors and multiple cytosolic receptors such as RIG-I-like helicases and NOD family proteins. NF-κB is required not only for the expression, but also for subsequent signal transduction of numerous downstream cytokines. NF-κB-responsive genes affect a diverse array of cellular processes including apoptosis and cell survival, and often directly control the course of a pathogen infection. In this review, we will examine signaling pathways leading to NF-κB activation during the innate immune response and mechanisms of pathogen-modulation of these pathways; the specifics of NF-κB-dependent gene programs, and the physiological consequences for the immune system caused by the absence of individual NF-κB subunits. |
| | |
Authors:
|
Anurupa Dev; Shankar Iyer; Bahram Razani; Genhong Cheng |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Current topics in microbiology and immunology Volume: 349 ISSN: 0070-217X ISO Abbreviation: Curr. Top. Microbiol. Immunol. Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-04-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0110513 Medline TA: Curr Top Microbiol Immunol Country: Germany |
Other Details:
|
Languages: eng Pagination: 115-43 Citation Subset: IM |
Affiliation:
|
Department of Microbiology, Immunology & Molecular Genetics, University of California Los Angeles, 615 Charles Young Dr S., 210A BSRB, Los Angeles, CA, 90095, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Vitamin E: cautionary issues.
Next Document: Prevalence and degree of hearing loss among males in Beaver Dam cohort: comparison of veterans and n...