| NF-κB: roles and regulation in different CD4(+) T-cell subsets. | |
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MedLine Citation:
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PMID: 23405894 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The nuclear factor-κB (NF-κB) family of transcription factors plays important roles in various biological processes including apoptosis, stress response, immunity, and inflammation. NF-κB signaling is involved in both immune cell development and function, and it is critical in modulation of the immune response through the transcriptional regulation of cytokine and chemokine expression. An area of great interest in T-cell-mediated adaptive immunity is the ability of naive CD4(+) T cells generated in the thymus to differentiate into various subsets including T-helper 1 (Th1), Th2, Th17, Th9, follicular helper T (Tfh), Th22, and regulatory T (Treg) cells, upon encountering different pathogens and microenvironments. In this review, we discuss the role of NF-κB pathway in the development and functional divergence of the different helper T-cell subsets as well as in regulatory T cells. |
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Authors:
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Hyunju Oh; Sankar Ghosh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Immunological reviews Volume: 252 ISSN: 1600-065X ISO Abbreviation: Immunol. Rev. Publication Date: 2013 Mar |
Date Detail:
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Created Date: 2013-02-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7702118 Medline TA: Immunol Rev Country: England |
Other Details:
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Languages: eng Pagination: 41-51 Citation Subset: IM |
Copyright Information:
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© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd. |
Affiliation:
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Department of Microbiology and Immunology, Columbia University, New York, NY. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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