Document Detail


The NET, the Trap and the Pathogen: Neutrophil Extracellular Traps in Cutaneous Immunity.
MedLine Citation:
PMID:  25421224     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Neutrophil extracellular traps (NETs), large chromatin structures casted with various proteins, are externalized by neutrophils upon induction by both self- and non-self stimuli. It has become clear that NETs are potent triggers of inflammation in autoimmune skin diseases. Moreover, the ability of NETs to trap pathogens suggests a crucial role in innate host defense. However, the outcome of the encounter between pathogens and NETs remains highly controversial. Here, we discuss recent insights into the morphology and formation of NETs, their role in skin inflammation, and how NETs might contribute to host protection against skin infection. This article is protected by copyright. All rights reserved.
Authors:
Alexander Stephan; Mario Fabri
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-24
Journal Detail:
Title:  Experimental dermatology     Volume:  -     ISSN:  1600-0625     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-25     Completed Date:  -     Revised Date:  2014-11-26    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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