| NDM-4 metallo-ss-lactamase with increased carbapenemase activity from Escherichia coli. | |
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MedLine Citation:
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PMID: 22252797 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A clinical Escherichia coli isolate resistant to all β-lactams including carbapenems expressed a novel metallo-β-lactamase (MBL) NDM-4 differing from NDM-1 by a single amino acid substitution (Met154Leu). NDM-4 possessed increased hydrolytic activity toward carbapenems and several cephalosporins as compared to NDM-1. This amino-acid substitution was not located into the known active sites of NDM-1 indicating that remote amino-acid subtitutions might also play a role in the extended activity of this MBL. |
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Authors:
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Patrice Nordmann; Anne E Boulanger; Laurent Poirel |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-17 |
Journal Detail:
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Title: Antimicrobial agents and chemotherapy Volume: - ISSN: 1098-6596 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0315061 Medline TA: Antimicrob Agents Chemother Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Service de Bactériologie-Virologie, INSERM U914 « Emerging Resistance to Antibiotics », Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris-Sud, K.-Bicêtre. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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