| The NBS1 genetic polymorphisms and the risk of the systemic lupus erythematosus in Taiwanese patients. | |
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MedLine Citation:
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PMID: 20571895 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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INTRODUCTION: Systemic lupus erythematosus (SLE), a multisystemic autoimmune disease, is characterized by the production of a range of autoantibodies against nuclear constituents and other self-antigens. The studies in DNA repair deficiencies in SLE patients have been recently investigated. AIMS: Few studies have been conducted on DNA repair gene polymorphisms and their role in autoimmune diseases. Our study purpose was to examine and compare NBS1 genotype distributions in a group of Taiwanese SLE patients and controls in Taiwan. PATIENTS AND METHODS: Participants were Taiwanese SLE patients and healthy controls. We studied associations among NBS1 polymorphisms--rs1061302, rs709816, and rs1805794--considering clinical features for the entire group and stratified subgroups. No statistically significant differences between the patients and controls were noted. However, we observed significant decreases in Ht1-GGG, Ht2-AAC, and Ht3-AGC in the SLE patients (Ht1-GGG, OR = 0.26, 95% CI: 0.16-0.41; Ht2-AAC, OR = 0.30, 95% CI: 0.17-0.53; Ht3-AGC, OR = 0.35, 95% CI: 0.19-0.71) and significant increases in Ht4-AAG, Ht5-AGG, and Ht8-GGC among the SLE patients. Combined, these results suggest an association between NBS1 genetic polymorphisms and Taiwanese SLE patients. |
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Authors:
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Ying-Ju Lin; Yu-Ching Lan; Lei Wan; Chung-Ming Huang; Cheng-Wen Lin; Kai-Chung Hsueh; Da-Yuan Chen; Ting-Hsu Lin; Fuu-Jen Tsai |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-23 |
Journal Detail:
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Title: Journal of clinical immunology Volume: 30 ISSN: 1573-2592 ISO Abbreviation: J. Clin. Immunol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102137 Medline TA: J Clin Immunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 643-8 Citation Subset: IM |
Affiliation:
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Department of Medical Research, China Medical University Hospital, No.2 Yuh-Der Road, Taichung 404, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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