Document Detail


The NBS1 genetic polymorphisms and the risk of the systemic lupus erythematosus in Taiwanese patients.
MedLine Citation:
PMID:  20571895     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
INTRODUCTION: Systemic lupus erythematosus (SLE), a multisystemic autoimmune disease, is characterized by the production of a range of autoantibodies against nuclear constituents and other self-antigens. The studies in DNA repair deficiencies in SLE patients have been recently investigated. AIMS: Few studies have been conducted on DNA repair gene polymorphisms and their role in autoimmune diseases. Our study purpose was to examine and compare NBS1 genotype distributions in a group of Taiwanese SLE patients and controls in Taiwan. PATIENTS AND METHODS: Participants were Taiwanese SLE patients and healthy controls. We studied associations among NBS1 polymorphisms--rs1061302, rs709816, and rs1805794--considering clinical features for the entire group and stratified subgroups. No statistically significant differences between the patients and controls were noted. However, we observed significant decreases in Ht1-GGG, Ht2-AAC, and Ht3-AGC in the SLE patients (Ht1-GGG, OR = 0.26, 95% CI: 0.16-0.41; Ht2-AAC, OR = 0.30, 95% CI: 0.17-0.53; Ht3-AGC, OR = 0.35, 95% CI: 0.19-0.71) and significant increases in Ht4-AAG, Ht5-AGG, and Ht8-GGC among the SLE patients. Combined, these results suggest an association between NBS1 genetic polymorphisms and Taiwanese SLE patients.
Authors:
Ying-Ju Lin; Yu-Ching Lan; Lei Wan; Chung-Ming Huang; Cheng-Wen Lin; Kai-Chung Hsueh; Da-Yuan Chen; Ting-Hsu Lin; Fuu-Jen Tsai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-23
Journal Detail:
Title:  Journal of clinical immunology     Volume:  30     ISSN:  1573-2592     ISO Abbreviation:  J. Clin. Immunol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102137     Medline TA:  J Clin Immunol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  643-8     Citation Subset:  IM    
Affiliation:
Department of Medical Research, China Medical University Hospital, No.2 Yuh-Der Road, Taichung 404, Taiwan.
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