| NBI-5788, an altered MBP83-99 peptide, induces a T-helper 2-like immune response in multiple sclerosis patients. | |
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MedLine Citation:
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PMID: 11079539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We assessed the immune response induced in multiple sclerosis (MS) patients who had received NBI-5788, an altered peptide ligand (APL) designed from an immunodominant region (83-99) of the neuroantigen myelin basic protein (MBP) (5, 10, or 20 mg subcutaneously weekly for 4 weeks). The mean frequency of NBI-5788-responsive T cells (stimulation index > 3) in MS patients treated with the APL was 35.8 +/- 12.8% (n = 7) compared with a mean frequency of 6.2 +/- 1.3% (n = 7) for the untreated patients. The mean frequency of whole MBP-responsive T cells in MS patients treated with the APL was not significantly different from that of untreated patients (16.4 +/- 5.7% vs 18.0 +/- 6.3%, respectively). NBI-5788-reactive T-cell lines generated from NBI-5788-treated patients exhibited an increased frequency of cross-reactivity with MBP peptide 83-99 compared with NBI-5788-reactive lines from control MS patients. Cytokine secretion by APL-reactive T-cell lines from NBI-5788-treated MS patients was more frequently T-helper 2-like compared with T-cell lines from untreated MS patients. These results demonstrate that subcutaneous administration of a soluble APL based on the MBP peptide 83-99 in MS patients can induce an APL-reactive immune response in which T lymphocytes cross-reactive with the immunodominant neuroantigen MBP secrete anti-inflammatory cytokines. The significant heterogeneity in immune response between individuals indicates the need for clinical laboratory correlation during the course of therapeutic trials. |
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Authors:
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P D Crowe; Y Qin; P J Conlon; J P Antel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of neurology Volume: 48 ISSN: 0364-5134 ISO Abbreviation: Ann. Neurol. Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2000-11-15 Completed Date: 2000-12-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 758-65 Citation Subset: IM |
Affiliation:
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Neurocrine Biosciences, San Diego, CA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibody Specificity / immunology Cytokines / drug effects, immunology* Female Humans Magnetic Resonance Imaging Male Middle Aged Multiple Sclerosis / drug therapy*, immunology*, pathology Myelin Basic Proteins / administration & dosage*, drug effects, immunology Peptide Fragments / administration & dosage*, pharmacology* T-Lymphocytes, Helper-Inducer / drug effects*, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Myelin Basic Proteins; 0/NBI 5788; 0/Peptide Fragments |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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