| NALCN: A Regulator of Pacemaker Activity. | |
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MedLine Citation:
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PMID: 22476981 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Pacemaker cells play a fundamental role in generating or regulating many essential biological rhythms. Spontaneous pacemaker activity is dependent on the function of an array of ion channels expressed in these cells. Recent characterization of a Na(+) leak channel (NALCN) has linked to its role in conducting the background Na(+) current that depolarizes resting membrane properties of pacemaker neurons. NALCN, along with Unc79 and Unc80, forms a protein complex that is involved in regulating intrinsic membrane and synaptic activities. In this review, we will discuss the current understanding of NALCN channel physiology and its role in regulating cell excitability and pacemaker activity. |
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Authors:
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Tom Z Lu; Zhong-Ping Feng |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-4 |
Journal Detail:
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Title: Molecular neurobiology Volume: - ISSN: 1559-1182 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8900963 Medline TA: Mol Neurobiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Physiology, Faculty of Medicine, University of Toronto, 3306 Medical Sciences Building, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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