| NADPH oxidases: new players in TNF-induced necrotic cell death. | |
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MedLine Citation:
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PMID: 17588511 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Necrosis is a caspase-independent cell death process involving the generation of reactive oxygen species (ROS). In a recent issue of Molecular Cell, Kim et al. (2007) reported on a novel TNF receptor 1 necrotic signaling complex inducing TRADD- and RIP1-dependent recruitment and activation of the ROS-generating Nox1 NADPH oxidase complex. |
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Authors:
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Tom Vanden Berghe; Wim Declercq; Peter Vandenabeele |
Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Molecular cell Volume: 26 ISSN: 1097-2765 ISO Abbreviation: Mol. Cell Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-06-25 Completed Date: 2007-08-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9802571 Medline TA: Mol Cell Country: United States |
Other Details:
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Languages: eng Pagination: 769-71 Citation Subset: IM |
Affiliation:
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Department for Molecular Biomedical Research, VIB, Technologiepark 927, B-9052, Ghent, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / pharmacology Butylated Hydroxyanisole / pharmacology Cell Line GTPase-Activating Proteins / chemistry, metabolism Humans Mice Multiprotein Complexes / metabolism NADPH Oxidase / metabolism* Necrosis / metabolism* Neuropeptides / chemistry, metabolism Signal Transduction* / drug effects Superoxides / metabolism* TNF Receptor-Associated Death Domain Protein / chemistry, metabolism Tumor Necrosis Factor-alpha / metabolism*, pharmacology rac GTP-Binding Proteins / chemistry, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/GTPase-Activating Proteins; 0/Multiprotein Complexes; 0/Neuropeptides; 0/Rac1 protein, mouse; 0/Ralbp1 protein, mouse; 0/TNF Receptor-Associated Death Domain Protein; 0/Tradd protein, mouse; 0/Tumor Necrosis Factor-alpha; 11062-77-4/Superoxides; 25013-16-5/Butylated Hydroxyanisole; EC 1.6.3.1/NADPH Oxidase; EC 3.6.5.2/rac GTP-Binding Proteins |
| Comments/Corrections | |
Comment On:
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Mol Cell. 2007 Jun 8;26(5):675-87
[PMID:
17560373
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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