Document Detail


NADPH oxidase-dependent oxidative stress in the failing heart: From pathogenic roles to therapeutic approach.
MedLine Citation:
PMID:  22080085     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Heart failure (HF) occurs when the adaptation mechanisms of the heart fail to compensate for stress factors, such as pressure overload, myocardial infarction, inflammation, diabetes, and cardiotoxic drugs, with subsequent ventricular hypertrophy, fibrosis, myocardial dysfunction, and chamber dilatation. Oxidative stress, defined as an imbalance between reactive oxygen species (ROS) generation and the capacity of antioxidant defense systems, has been authenticated as a pivotal player in the cardiopathogenesis of the various HF subtypes. The family of NADPH oxidases has been investigated as a key enzymatic source of ROS in the pathogenesis of HF. In this review, we discuss the importance of NADPH oxidase-dependent ROS generation in the various subtypes of HF and its implications. A better understanding of the pathogenic roles of NADPH oxidases in the failing heart is likely to provide novel therapeutic strategies for the prevention and treatment of HF.
Authors:
Yanti Octavia; Hans Peter Brunner-La Rocca; An L Moens
Related Documents :
17033395 - Does chlamydia pneumoniae cause coronary heart disease?
20680815 - Experimental cell transplantation therapy in rat myocardial infarction model including ...
16460265 - Cardiac regeneration: repopulating the heart.
20056945 - Intramyocardial fibroblast myocyte communication.
17893005 - Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor m...
24752025 - Cardiac advanced life support-surgical guideline: overview and implementation.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-3
Journal Detail:
Title:  Free radical biology & medicine     Volume:  -     ISSN:  1873-4596     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709159     Medline TA:  Free Radic Biol Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Physiological effects of oxidized phospholipids and their cellular signaling mechanisms in inflammat...
Next Document:  Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in prima...