| NADPH-diaphorase distribution in the rabbit superior colliculus and co-localization with calcium-binding proteins. | |
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MedLine Citation:
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PMID: 12033734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitric oxide (NO) and calcium-binding proteins (CaBP) are important neuromodulators implicated in brain plasticity and brain disease. In addition, the mammalian superior colliculus (SC) has one of the highest concentrations of NO within the brain. The present study was designed to determine the distribution of nitric oxide-synthesizing neurons in the SC of the rabbit by enzyme histochemistry for reduced nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d), and its degree of co-localization with CaBP, parvalbumin (PV) and calbindin (CB). NADPH-d-labelled fibres formed dense patches of terminal buttons within the intermediate grey layer and streams of fibres within the deepest layers of SC. Cells expressing NOS constitute a subpopulation of neurons in which practically all cell types are represented. Combined PV/NADPH-d experiments showed a complete lack of co-localization within individual neurons and fibres. On the contrary, double-labelled neurons appeared in CB/NADPH-d-stained sections, only in the superficial layers, and mostly in the SGS and SO. These cells, which were intermingled with other neurons containing either NADPH-d or CB, appear to be a subtype of narrow-field and wide-field vertical cells, and display an anterior-posterior gradient of density. Owing to the involvement of the superficial layers of the SC in the organization and integration of the visual information, it is suggested that these neurons may play a concrete role within the visual circuits. Our data indicate a clear selectivity in the expression of NADPH-d, PV and CB in the SC, and that NO and CB probably serve as co-modulators and/or co-transmitters in the connectivity of the superficial layers of this midbrain structure. |
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Authors:
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Juncal González-Soriano; Julio Contreras-Rodríguez; Pilar Martínez-Sainz; Susana Martín-Palacios; Pilar Marín-García; Elisia Rodríguez-Veiga |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of anatomy Volume: 200 ISSN: 0021-8782 ISO Abbreviation: J. Anat. Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-05-29 Completed Date: 2002-07-12 Revised Date: 2013-06-09 |
Medline Journal Info:
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Nlm Unique ID: 0137162 Medline TA: J Anat Country: England |
Other Details:
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Languages: eng Pagination: 297-308 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Embryology, Veterinary Faculty-U.C.M., Ciudad Universitaria, Madrid, Spain. juncalgs@vet.ucm.es |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium-Binding Protein, Vitamin D-Dependent / analysis Calcium-Binding Proteins / analysis* Female NADPH Dehydrogenase / analysis* Neurons / cytology, enzymology Parvalbumins / analysis Rabbits Superior Colliculi / chemistry, enzymology* |
| Chemical | |
Reg. No./Substance:
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0/Calcium-Binding Protein, Vitamin D-Dependent; 0/Calcium-Binding Proteins; 0/Parvalbumins; 0/calbindin; 0/calcium-binding protein (brain); EC 1.6.99.1/NADPH Dehydrogenase |
| Comments/Corrections | |
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