Document Detail


The NAD metabolome - a key determinant of cancer cell biology.
MedLine Citation:
PMID:  23018234     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
NAD is a vital molecule in all organisms. It is a key component of both energy and signal transduction - processes that undergo crucial changes in cancer cells. NAD(+)-dependent signalling pathways are many and varied, and they regulate fundamental events such as transcription, DNA repair, cell cycle progression, apoptosis and metabolism. Many of these processes have been linked to cancer development. Given that NAD(+)-dependent signalling reactions involve the degradation of the molecule, permanent nucleotide resynthesis through different biosynthetic pathways is crucial for incessant cancer cell proliferation. This necessity supports the targeting of NAD metabolism as a new therapeutic concept for cancer treatment.
Authors:
Alberto Chiarugi; Christian Dölle; Roberta Felici; Mathias Ziegler
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-28
Journal Detail:
Title:  Nature reviews. Cancer     Volume:  -     ISSN:  1474-1768     ISO Abbreviation:  Nat. Rev. Cancer     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101124168     Medline TA:  Nat Rev Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Preclinical and Clinical Pharmacology, University of Firenze, 50139, Italy.
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