Document Detail


NAD+ as a signaling molecule modulating metabolism.
MedLine Citation:
PMID:  22345172     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability of NAD(+) to act as a metabolic cofactor and as a rate-limiting cosubstrate for many enzymes, particularly the sirtuins, has led to the identification of a pivotal role of NAD(+) levels in the control of whole-body metabolic homeostasis. Bioavailability and compartmentalization of NAD(+) have become highly relevant issues that we need to understand in order to elucidate how NAD(+) acts both as a readout of the metabolic milieu and as an effector triggering appropriate cellular adaptations.
Authors:
C Cantó; J Auwerx
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-02-17
Journal Detail:
Title:  Cold Spring Harbor symposia on quantitative biology     Volume:  76     ISSN:  1943-4456     ISO Abbreviation:  Cold Spring Harb. Symp. Quant. Biol.     Publication Date:  2011  
Date Detail:
Created Date:  2012-06-15     Completed Date:  2012-10-17     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  1256107     Medline TA:  Cold Spring Harb Symp Quant Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  291-8     Citation Subset:  IM    
Affiliation:
Nestlé Institute of Health Sciences, CH-1015, Lausanne, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Metabolism*
NAD / metabolism*
Signal Transduction*
Sirtuins / metabolism
Grant Support
ID/Acronym/Agency:
231138//European Research Council; DK59820/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
53-84-9/NAD; EC 3.5.1.-/Sirtuins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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